› 3tkm

X-ray diffraction
1.95Å resolution

Crystal structure PPAR delta binding GW0742

Released:
DOI: 10.2210/pdb3tkm/pdb
PDB entry 3tkm coloured by chain, front view.
PDB entry 3tkm coloured by chain, side view.
PDB entry 3tkm coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural insights into human peroxisome proliferator activated receptor delta (PPAR-delta) selective ligand binding.
Batista FA, Trivella DB, Bernardes A, Gratieri J, Oliveira PS, Figueira AC, Webb P, Polikarpov I
PLoS One 7 e33643 (2012)
PMID: 22606221

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169863 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxisome proliferator-activated receptor delta Chain: A
Molecule details ›
Chain: A
Length: 275 amino acids
Theoretical weight: 31.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q03181 (Residues: 171-441; Coverage: 62%)
Gene names: NR1C2, PPARB, PPARD
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

2 bound ligands:
Ligand GW0 1 x GW0
Ligand GOL 1 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: LNLS BEAMLINE W01B-MX2
Spacegroup: P212121
Unit cell:
a: 35.466Å b: 74.766Å c: 96.287Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.199 0.197 0.245
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

6 review citations

The Role of PPAR-δ in Metabolism, Inflammation, and Cancer: Many Characters of a Critical Transcription Factor.
Liu et al. (2018)
5 more

20 mentions without citation

Activation of PPARδ: from computer modelling to biological effects.
Kahremany et al. (2015)
19 more