3tj6 Summary


human vinculin head domain (Vh1, residues 1-258) in complex with the vinculin binding site of the surface cell antigen 4 (sca4-VBS-C; residues 812-835) from Rickettsia rickettsii

The structure was published by Park, H., Lee, J.H., Gouin, E., Cossart, P., and Izard, T., in 2011 in a paper entitled "The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.76 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Antigenic heat-stable 120 kDa protein.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (1-257) (VINC_HUMAN)search Homo sapienssearch 94% 257 98%
B Antigenic heat-stable 120 kDa protein B0BXR4 (812-834) (B0BXR4_RICRO)search Rickettsia rickettsii str. Iowasearch < 90% 23 100%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 257) Vinculin Homo sapiens
B0BXR4 (812 - 834) Antigenic heat-stable 120 kDa protein Rickettsia rickettsii str. Iowa

Chain Structural classification (CATH) Sequence family (Pfam)
A (P18206) Four Helix Bundle (Hemerythrin (Met), subunit A)search PF01044: Vinculin familysearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P18206) structural molecule activitysearch actin filament bindingsearch cell adhesionsearch cell-matrix adhesionsearch actin cytoskeletonsearch

Chain InterPro annotation
A Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch Vinculinsearch