3t85 Summary


Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates

The structure was published by Lopez, M., Vu, H., Wang, C.K., et al., Innocenti, A., Supuran, C.T., and Poulsen, S.A., in 2011 in a paper entitled "Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.4 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (P00918) cytoplasmsearch plasma membranesearch cytosolsearch axonsearch extracellular vesicular exosomesearch membranesearch basolateral plasma membranesearch extracellular spacesearch microvillussearch apical part of cellsearch myelin sheathsearch bicarbonate transportsearch positive regulation of synaptic transmission, GABAergicsearch response to steroid hormonesearch positive regulation of dipeptide transmembrane transportsearch regulation of intracellular pHsearch response to zinc ionsearch one-carbon metabolic processsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch regulation of chloride transportsearch odontogenesis of dentin-containing toothsearch response to organic substancesearch kidney developmentsearch secretionsearch response to estrogensearch regulation of anion transportsearch small molecule metabolic processsearch positive regulation of cellular pH reductionsearch positive regulation of osteoclast differentiationsearch response to pHsearch angiotensin-activated signaling pathwaysearch protein bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch lyase activitysearch metal ion bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch