3t83 Summary


Human Carbonic Anhydrase II in complex with Acetylated Carbohydrate Sulfamates

The structure was published by Lopez, M., Vu, H., Wang, C.K., et al., Innocenti, A., Supuran, C.T., and Poulsen, S.A., in 2011 in a paper entitled "Promiscuity of carbonic anhydrase II. Unexpected ester hydrolysis of carbohydrate-based sulfamate inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P00918) angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch regulation of chloride transportsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch regulation of anion transportsearch bicarbonate transportsearch response to pHsearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch kidney developmentsearch response to zinc ionsearch secretionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch response to organic substancesearch response to estrogensearch small molecule metabolic processsearch zinc ion bindingsearch carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch cytoplasmsearch extracellular spacesearch axonsearch membranesearch microvillussearch myelin sheathsearch apical part of cellsearch plasma membranesearch basolateral plasma membranesearch cytosolsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch