3t5z Summary


Crystal structure of the human carbonic anhydrase II in complex with N-methoxy-benzenesulfonamide

The structure was published by Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., and De Simone, G., in 2011 in a paper entitled "Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.65 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 258 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) regulation of intracellular pHsearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch angiotensin-activated signaling pathwaysearch regulation of anion transportsearch positive regulation of bone resorptionsearch positive regulation of cellular pH reductionsearch odontogenesis of dentin-containing toothsearch small molecule metabolic processsearch response to organic substancesearch secretionsearch response to pHsearch kidney developmentsearch bicarbonate transportsearch response to steroid hormonesearch carbon dioxide transportsearch response to estrogensearch positive regulation of osteoclast differentiationsearch plasma membranesearch cytosolsearch basolateral plasma membranesearch extracellular vesicular exosomesearch microvillussearch extracellular spacesearch cytoplasmsearch apical part of cellsearch membranesearch axonsearch zinc ion bindingsearch lyase activitysearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch