3t5u Summary


Crystal structure of the human carbonic anhydrase II in complex with N-hydroxy benzenesulfonamide

The structure was published by Di Fiore, A., Maresca, A., Alterio, V., Supuran, C.T., and De Simone, G., in 2011 in a paper entitled "Carbonic anhydrase inhibitors: X-ray crystallographic studies for the binding of N-substituted benzenesulfonamides to human isoform II." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.75 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) metal ion bindingsearch carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch cytosolsearch membranesearch cytoplasmsearch myelin sheathsearch extracellular vesicular exosomesearch plasma membranesearch extracellular spacesearch apical part of cellsearch microvillussearch basolateral plasma membranesearch axonsearch regulation of chloride transportsearch regulation of intracellular pHsearch response to pHsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch response to zinc ionsearch kidney developmentsearch bicarbonate transportsearch one-carbon metabolic processsearch positive regulation of osteoclast differentiationsearch positive regulation of cellular pH reductionsearch positive regulation of dipeptide transmembrane transportsearch response to estrogensearch small molecule metabolic processsearch secretionsearch response to steroid hormonesearch angiotensin-activated signaling pathwaysearch positive regulation of bone resorptionsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch