3t1e Summary

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The structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a 4-helix bundle stalk

The structure was published by Yuan, P., Swanson, K.A., Leser, G.P., Paterson, R.G., Lamb, R.A., and Jardetzky, T.S., in 2011 in a paper entitled "Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.301 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Hemagglutinin-neuraminidase.

The molecule most likely forms homotetramers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemagglutinin-neuraminidase P12554 (49-570) (HN_NDVA)search Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)search 92% 537 83%
B Hemagglutinin-neuraminidase P12554 (49-570) (HN_NDVA)search Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)search 92% 537 83%
E Hemagglutinin-neuraminidase P12554 (49-570) (HN_NDVA)search Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)search 92% 537 83%
F Hemagglutinin-neuraminidase P12554 (49-570) (HN_NDVA)search Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)search 92% 537 83%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P12554 (49 - 570) Hemagglutinin-neuraminidase Newcastle disease virus (STRAIN AUSTRALIA-VICTORIA/32)

Chain Sequence family (Pfam)
A, B, E, F (P12554) PF00423: Haemagglutinin-neuraminidasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, E, F (P12554) host cell surface receptor bindingsearch exo-alpha-(2->3)-sialidase activitysearch hydrolase activitysearch exo-alpha-sialidase activitysearch exo-alpha-(2->8)-sialidase activitysearch exo-alpha-(2->6)-sialidase activitysearch metabolic processsearch viral life cyclesearch viral processsearch virion attachment to host cellsearch viral entry into host cellsearch host cell membranesearch viral envelopesearch virion membranesearch host cell plasma membranesearch virionsearch integral component of membranesearch membranesearch

Chain InterPro annotation
A, B, E, F Haemagglutinin-neuraminidasesearch Sialidasessearch Haemagglutinin-neuraminidase, paramyxovirussearch