3soc Summary

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Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with a quinazolin

A publication describing this structure is not available. The depositing authors are Chaikuad, A.search; Williams, E.search; Mahajan, P.search; Cooper, C.D.O.search; Sanvitale, C.search; Vollmar, M.search; Muniz, J.R.C.search; Yue, W.W.search; von Delft, F.search; Weigelt, J.search; Arrowsmith, C.H.search; Edwards, A.M.search; Bountra, C.search; Bullock, A.search; Structural Genomics Consortium (SGC)search

This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Activin receptor type-2A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activin receptor type-2A P27037 (191-488) (AVR2A_HUMAN)search Homo sapienssearch < 90% 322 95%
B Activin receptor type-2A P27037 (191-488) (AVR2A_HUMAN)search Homo sapienssearch < 90% 322 95%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27037 (191 - 488) Activin receptor type-2A Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P27037) receptor signaling protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch membranesearch

Chain InterPro annotation
A, B Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch