› 3sla

X-ray diffraction
2.5Å resolution

X-ray structure of first four repeats of human beta-catenin

Released:
DOI: 10.2210/pdb3sla/pdb
PDB entry 3sla coloured by chain, front view.
PDB entry 3sla coloured by chain, side view.
PDB entry 3sla coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
de la Roche M, Rutherford TJ, Gupta D, Veprintsev DB, Saxty B, Freund SM, Bienz M
Nat Commun 3 680 (2012)
PMID: 22353711

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152831 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Catenin beta-1 Chains: A, B, C, D, E
Molecule details ›
Chains: A, B, C, D, E
Length: 168 amino acids
Theoretical weight: 18.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P35222 (Residues: 141-306; Coverage: 21%)
Gene names: CTNNB, CTNNB1, OK/SW-cl.35, PRO2286
Sequence domains: Armadillo/beta-catenin-like repeat
Structure domains: Leucine-rich Repeat Variant

Ligands and Environments

2 bound ligands:
Ligand GOL 8 x GOL
Ligand NA 2 x NA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: P41212
Unit cell:
a: 90.79Å b: 90.79Å c: 364.34Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.218 0.277
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

32 review citations

Wnt signaling in stem and cancer stem cells.
Holland et al. (2013)
31 more

1 mention without citation

An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
de la Roche et al. (2012)