3s76 Summary


The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase

The structure was published by Snyder, P.W., Mecinovic, J., Moustakas, D.T., et al., Heroux, A., Sherman, W., and Whitesides, G.M., in 2011 in a paper entitled "Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) positive regulation of cellular pH reductionsearch response to pHsearch response to steroid hormonesearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch one-carbon metabolic processsearch response to zinc ionsearch secretionsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch regulation of chloride transportsearch bicarbonate transportsearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of dipeptide transmembrane transportsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch regulation of anion transportsearch morphogenesis of an epitheliumsearch membranesearch cytoplasmsearch cytosolsearch apical part of cellsearch extracellular vesicular exosomesearch plasma membranesearch extracellular spacesearch myelin sheathsearch microvillussearch axonsearch basolateral plasma membranesearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch