3s76 Summary


The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase

The structure was published by Snyder, P.W., Mecinovic, J., Moustakas, D.T., et al., Heroux, A., Sherman, W., and Whitesides, G.M., in 2011 in a paper entitled "Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch metal ion bindingsearch lyase activitysearch protein bindingsearch zinc ion bindingsearch one-carbon metabolic processsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch bicarbonate transportsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch response to steroid hormonesearch regulation of intracellular pHsearch positive regulation of cellular pH reductionsearch regulation of anion transportsearch positive regulation of osteoclast differentiationsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch secretionsearch cellular response to fluid shear stresssearch response to estrogensearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch response to zinc ionsearch positive regulation of bone resorptionsearch morphogenesis of an epitheliumsearch cytoplasmsearch extracellular vesicular exosomesearch plasma membranesearch membranesearch extracellular spacesearch microvillussearch myelin sheathsearch apical part of cellsearch cytosolsearch axonsearch basolateral plasma membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch