3s76 Summary


The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase

The structure was published by Snyder, P.W., Mecinovic, J., Moustakas, D.T., et al., Heroux, A., Sherman, W., and Whitesides, G.M., in 2011 in a paper entitled "Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) carbonate dehydratase activitysearch protein bindingsearch lyase activitysearch metal ion bindingsearch zinc ion bindingsearch bicarbonate transportsearch morphogenesis of an epitheliumsearch response to steroid hormonesearch response to estrogensearch cellular response to fluid shear stresssearch one-carbon metabolic processsearch regulation of intracellular pHsearch positive regulation of bone resorptionsearch response to zinc ionsearch positive regulation of synaptic transmission, GABAergicsearch kidney developmentsearch regulation of chloride transportsearch positive regulation of dipeptide transmembrane transportsearch angiotensin-activated signaling pathwaysearch small molecule metabolic processsearch response to organic substancesearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch secretionsearch response to pHsearch regulation of anion transportsearch positive regulation of osteoclast differentiationsearch plasma membranesearch cytosolsearch cytoplasmsearch microvillussearch apical part of cellsearch membranesearch extracellular vesicular exosomesearch extracellular spacesearch basolateral plasma membranesearch axonsearch myelin sheathsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch