3s72 Summary


The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase

The structure was published by Snyder, P.W., Mecinovic, J., Moustakas, D.T., et al., Heroux, A., Sherman, W., and Whitesides, G.M., in 2011 in a paper entitled "Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
B (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
B (P00918) response to steroid hormonesearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch bicarbonate transportsearch regulation of intracellular pHsearch regulation of anion transportsearch response to zinc ionsearch regulation of chloride transportsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch response to pHsearch response to organic substancesearch small molecule metabolic processsearch positive regulation of bone resorptionsearch response to estrogensearch angiotensin-activated signaling pathwaysearch secretionsearch metal ion bindingsearch zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch protein bindingsearch membranesearch cytosolsearch apical part of cellsearch extracellular vesicular exosomesearch axonsearch microvillussearch plasma membranesearch cytoplasmsearch basolateral plasma membranesearch extracellular spacesearch myelin sheathsearch

Chain InterPro annotation
B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch