3s5l Summary details

pdbe.org/3s5l/summary_details
spacer Crystal structure of CD4 mutant bound to HLA-DR1
Summary
Header IMMUNE SYSTEMsearch
Method X-RAY DIFFRACTION
Experiment Resolution: 2.1 Å, R-factor: 23.4%, Free R-factor: 26.8%, Spacegroup: P 21 21 21
Released 21/09/2011, deposition: 23/05/2011, last revision: 16/11/2011
Authors Li, Y.search
Primary citation Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
PROC.NATL.ACAD.SCI.USAsearch vol:108, pag:15960-15965 (2011) [PubMed 21900604 ]search
Keywords protein-protein complexsearch, IMMUNE SYSTEMsearch, co-receptorsearch
Organism Homo sapiens(human) 9606search(A D B E C F G H)
UniProt P01903search (A D)
P04229search (B E)
P03437search (C F)
P01730search (G H)
Solvent A, B, C, D, E, F, G, H
Related entries 3s4s
Polymers
Chain Id Name Type UniProt Residues in sample sequence % of sample sequence observed
A, D HLA class II histocompatibility antigen, DR alpha chain Protein P01903 (DRA_HUMAN)search
182 98%
B, E HLA class II histocompatibility antigen, DRB1-1 beta chain Protein P04229 (2B11_HUMAN)search
193 98%
C, F HA peptide Protein P03437 (HEMA_I68A0)search
13 100%
G, H T-cell surface glycoprotein CD4 Protein P01730 (CD4_HUMAN)search
191 92%
Heterogens
Chain Id Name Ligands
A, D, B, E, G, H GLYCEROL GOL search
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