spacer Crystal structure of CD4 mutant bound to HLA-DR1
UniProt sequence   UniProt   CATH   Pfam   SCOP   Secondary structure   UniProt features   FASTA string  

Chain A: HLA class II histocompatibility antigen, DR alpha chain

1 I K E E H V I I Q A E F Y L N P D Q S G E F M F D F D G D E I F H V D M A K K E T V W R L E E F G R F A S F E A Q G A L
I K E E H V I I Q A E F Y L N P D Q S G E F M F D F D G D E I F H V D M A K K E T V W R L E E F G R F A S F E A Q G A L
26
61 A N I A V D K A N L E I M T K R S N Y T P I T N V P P E V T V L T N S P V E L R E P N V L I C F I D K F T P P V V N V T
A N I A V D K A N L E I M T K R S N Y T P I T N V P P E V T V L T N S P V E L R E P N V L I C F I D K F T P P V V N V T
121 W L R N G K P V T T G V S E T V F L P R E D H L F R K F H Y L P F L P S T E D V Y D C R V E H W G L D E P L L K Q W E F
W L R N G K P V T T G V S E T V F L P R E D H L F R K F H Y L P F L P S T E D V Y D C R V E H W G L D E P L L K H W E F
181 D A
D A
207

Regions

UniProt

P01903
26 .. 207 > 1 .. 182 (PDB)

Pfam

PF00993
4 .. 84 (PDB)
PF07654
93 .. 175 (PDB)

Chain B: HLA class II histocompatibility antigen, DRB1-1 beta chain

1 M G D T R P R F L W Q L K F E C H F F N G T E R V R L L E R C I Y N Q E E S V R F D S D V G E Y R A V T E L G R P D A E
G D T R P R F L W Q L K F E C H F F N G T E R V R L L E R C I Y N Q E E S V R F D S D V G E Y R A V T E L G R P D A E
30
61 Y W N S Q K D L L E Q R R A A V D T Y C R H N Y G V G E S F T V Q R R V E P K V T V Y P S K T Q P L Q H H N L L V C S V
Y W N S Q K D L L E Q R R A A V D T Y C R H N Y G V G E S F T V Q R R V E P K V T V Y P S K T Q P L Q H H N L L V C S V
121 S G F Y P G S I E V R W F R N G Q E E K A G V V S T G L I Q N G D W T F Q T L V M L E T V P R S G E V Y T C Q V E H P S
S G F Y P G S I E V R W F R N G Q E E K A G V V S T G L I Q N G D W T F Q T L V M L E T V P R S G E V Y T C Q V E H P S
181 V T S P L T V E W R A R S
V T S P L T V E W R A R S
221

Regions

UniProt

P04229
30 .. 221 > 1 .. 192 (PDB)

Pfam

PF00969
13 .. 87 (PDB)
PF07654
103 .. 185 (PDB)

Chain C: Hemagglutinin peptide

1 P K Y V K Q N T L K L A T
P K Y V K Q N T L K L A T
322 334

Regions

UniProt

P03437
322 .. 334 > 3 .. 15 (PDB)

Pfam

PF00509
3 .. 15 (PDB)

Chain D: HLA class II histocompatibility antigen, DR alpha chain

1 I K E E H V I I Q A E F Y L N P D Q S G E F M F D F D G D E I F H V D M A K K E T V W R L E E F G R F A S F E A Q G A L
I K E E H V I I Q A E F Y L N P D Q S G E F M F D F D G D E I F H V D M A K K E T V W R L E E F G R F A S F E A Q G A L
26
61 A N I A V D K A N L E I M T K R S N Y T P I T N V P P E V T V L T N S P V E L R E P N V L I C F I D K F T P P V V N V T
A N I A V D K A N L E I M T K R S N Y T P I T N V P P E V T V L T N S P V E L R E P N V L I C F I D K F T P P V V N V T
121 W L R N G K P V T T G V S E T V F L P R E D H L F R K F H Y L P F L P S T E D V Y D C R V E H W G L D E P L L K Q W E F
W L R N G K P V T T G V S E T V F L P R E D H L F R K F H Y L P F L P S T E D V Y D C R V E H W G L D E P L L K H W E F
181 D A
D A
207

Regions

UniProt

P01903
26 .. 207 > 1 .. 182 (PDB)

Pfam

PF00993
4 .. 84 (PDB)
PF07654
93 .. 175 (PDB)

Chain E: HLA class II histocompatibility antigen, DRB1-1 beta chain

1 M G D T R P R F L W Q L K F E C H F F N G T E R V R L L E R C I Y N Q E E S V R F D S D V G E Y R A V T E L G R P D A E
G D T R P R F L W Q L K F E C H F F N G T E R V R L L E R C I Y N Q E E S V R F D S D V G E Y R A V T E L G R P D A E
30
61 Y W N S Q K D L L E Q R R A A V D T Y C R H N Y G V G E S F T V Q R R V E P K V T V Y P S K T Q P L Q H H N L L V C S V
Y W N S Q K D L L E Q R R A A V D T Y C R H N Y G V G E S F T V Q R R V E P K V T V Y P S K T Q P L Q H H N L L V C S V
121 S G F Y P G S I E V R W F R N G Q E E K A G V V S T G L I Q N G D W T F Q T L V M L E T V P R S G E V Y T C Q V E H P S
S G F Y P G S I E V R W F R N G Q E E K A G V V S T G L I Q N G D W T F Q T L V M L E T V P R S G E V Y T C Q V E H P S
181 V T S P L T V E W R A R S
V T S P L T V E W R A R S
221

Regions

UniProt

P04229
30 .. 221 > 1 .. 192 (PDB)

Pfam

PF00969
13 .. 87 (PDB)
PF07654
103 .. 185 (PDB)

Chain F: Hemagglutinin peptide

1 P K Y V K Q N T L K L A T
P K Y V K Q N T L K L A T
322 334

Regions

UniProt

P03437
322 .. 334 > 3 .. 15 (PDB)

Pfam

PF00509
3 .. 15 (PDB)

Chain G: T-cell surface glycoprotein CD4

1 D L G S K K V V L G K K G D T V E L T C T A S Q K K S I Q F H W K N S N Q I K I L G N Y G S F L W K G P S K L N D R A D
K K V V L G K K G D T V E L T C T A S Q K K S I Q F H W K N S N Q I K I L G N Q G S F L T K G P S K L N D R A D
26
61 S R R S L W D Q G N F P L I I K N L K I E D S D T Y I C E V E D Q K E E V Q L L V F G L T A N S D T H L L Q G Q S L T L
S R R S L W D Q G N F P L I I K N L K I E D S D T Y I C E V E D Q K E E V Q L L V F G L T A N S D T H L L Q G Q S L T L
121 T L E S P P G S S P S V Q C R S P R G K N I Q G G K T L S V S Q L E L Q D S G T W T C T V L Q N Q K K V E F K I D I V V
T L E S P P G S S P S V Q C R S P R G K N I Q G G K T L S V S Q L E L Q D S G T W T C T V L Q N Q K K V E F K I D I V V
181 L A A A A H H H H H H
L A
203

Regions

UniProt

P01730
26 .. 203 > 1 .. 178 (PDB)

Pfam

PF07686
1 .. 104 (PDB)
PF05790
105 .. 178 (PDB)

Chain H: T-cell surface glycoprotein CD4

1 D L G S K K V V L G K K G D T V E L T C T A S Q K K S I Q F H W K N S N Q I K I L G N Y G S F L W K G P S K L N D R A D
K K V V L G K K G D T V E L T C T A S Q K K S I Q F H W K N S N Q I K I L G N Q G S F L T K G P S K L N D R A D
26
61 S R R S L W D Q G N F P L I I K N L K I E D S D T Y I C E V E D Q K E E V Q L L V F G L T A N S D T H L L Q G Q S L T L
S R R S L W D Q G N F P L I I K N L K I E D S D T Y I C E V E D Q K E E V Q L L V F G L T A N S D T H L L Q G Q S L T L
121 T L E S P P G S S P S V Q C R S P R G K N I Q G G