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Crystal Structure of the 3-Dehydroquinate Dehydratase (aroD) from Salmonella enterica Typhimurium LT2 with Malonate and Boric Acid at the Active Site

Source organism: Salmonella enterica subsp. enterica serovar Typhimurium
Biochemical function: lyase activity
Biological process: 3,4-dihydroxybenzoate biosynthetic process
Cellular component: not assigned

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EC 4.2.1.10: 3-dehydroquinate dehydratase

Reaction catalysed:
3-dehydroquinate = 3-dehydroshikimate + H(2)O
Systematic name:
3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)
Alternative Name(s):
  • 3-dehydroquinase
  • 3-dehydroquinate hydro-lyase
  • 3-dehydroquinate hydrolase
  • 5-dehydroquinase
  • 5-dehydroquinate dehydratase
  • 5-dehydroquinate hydro-lyase
  • DHQase
  • Dehydroquinase
  • Dehydroquinate dehydratase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF01487
Domain description: Type I 3-dehydroquinase
Occurring in:
  1. 3-dehydroquinate dehydratase
The deposited structure of PDB entry 3s42 contains 2 copies of Pfam domain PF01487 (Type I 3-dehydroquinase) in 3-dehydroquinate dehydratase. Showing 1 copy in chain A [auth B].

InterPro InterPro annotations
IPR001381
Domain description: 3-dehydroquinate dehydratase type I
Occurring in:
  1. 3-dehydroquinate dehydratase
IPR018508
Domain description: 3-dehydroquinate dehydratase, active site
Occurring in:
  1. 3-dehydroquinate dehydratase
IPR013785
Domain description: Aldolase-type TIM barrel
Occurring in:
  1. 3-dehydroquinate dehydratase
IPR023393
Domain description: START-like domain superfamily
Occurring in:
  1. 3-dehydroquinate dehydratase

Structure domain

CATH CATH domain
3.20.20.70
Class: Alpha Beta
Architecture: Alpha-Beta Barrel
Topology: TIM Barrel
Homology: Aldolase class I
Occurring in:
  1. 3-dehydroquinate dehydratase
The deposited structure of PDB entry 3s42 contains 2 copies of CATH domain 3.20.20.70 (TIM Barrel) in 3-dehydroquinate dehydratase. Showing 1 copy in chain A [auth B].

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