PDB entry 3s2o (supersedes 3msm)
Fragment based discovery and optimisation of bace-1 inhibitors
The structure was published by Madden, J., Dod, J.R., Godemann, R., et al., Barker, J., Dyekjaer, J.D., and Hesterkamp, T., in 2010 in a paper entitled "Fragment-based discovery and optimization of BACE1 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Beta-secretase 1. This molecule has the UniProt identifier P56817 (BACE1_HUMAN). The sample contained 408 residues which is < 90% of the natural sequence. Out of 408 residues 377 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: