3rz7 Summary

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Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase

The structure was published by Mecinovic, J., Snyder, P.W., Mirica, K.A., et al., Moustakas, D.T., Heroux, A., and Whitesides, G.M., in 2011 in a paper entitled "Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.8 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch lyase activitysearch metal ion bindingsearch protein bindingsearch basolateral plasma membranesearch cytoplasmsearch extracellular vesicular exosomesearch extracellular spacesearch cytosolsearch plasma membranesearch membranesearch apical part of cellsearch microvillussearch axonsearch positive regulation of dipeptide transmembrane transportsearch regulation of anion transportsearch secretionsearch small molecule metabolic processsearch response to pHsearch angiotensin-activated signaling pathwaysearch response to zinc ionsearch positive regulation of cellular pH reductionsearch kidney developmentsearch bicarbonate transportsearch response to steroid hormonesearch regulation of intracellular pHsearch carbon dioxide transportsearch response to estrogensearch positive regulation of osteoclast differentiationsearch morphogenesis of an epitheliumsearch one-carbon metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of bone resorptionsearch response to organic substancesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch