3rz0 Summary

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Fluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the Hydrophobic Wall of Carbonic Anhydrase

The structure was published by Mecinovic, J., Snyder, P.W., Mirica, K.A., et al., Moustakas, D.T., Heroux, A., and Whitesides, G.M., in 2011 in a paper entitled "Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.798 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 98% 259 99%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
B (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
B (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch protein bindingsearch lyase activitysearch metal ion bindingsearch one-carbon metabolic processsearch small molecule metabolic processsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch bicarbonate transportsearch regulation of chloride transportsearch response to organic substancesearch regulation of anion transportsearch positive regulation of cellular pH reductionsearch positive regulation of bone resorptionsearch regulation of intracellular pHsearch positive regulation of synaptic transmission, GABAergicsearch odontogenesis of dentin-containing toothsearch secretionsearch kidney developmentsearch positive regulation of osteoclast differentiationsearch response to estrogensearch response to pHsearch response to steroid hormonesearch cytosolsearch membranesearch plasma membranesearch apical part of cellsearch cytoplasmsearch basolateral plasma membranesearch extracellular vesicular exosomesearch axonsearch microvillussearch myelin sheathsearch extracellular spacesearch

Chain InterPro annotation
B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch