3ryj Summary


Carbonic Anhydrase complexed with 4-sulfamoyl-N-(2,2,2-trifluoroethyl)benzamide

The structure was published by Mecinovic, J., Snyder, P.W., Mirica, K.A., et al., Moustakas, D.T., Heroux, A., and Whitesides, G.M., in 2011 in a paper entitled "Fluoroalkyl and alkyl chains have similar hydrophobicities in binding to the "hydrophobic wall" of carbonic anhydrase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.39 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 259 residues which is 100% of the natural sequence. Out of 259 residues 256 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
B Carbonic anhydrase 2 P00918 (2-260) (CAH2_HUMAN)search Homo sapienssearch 96% 259 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (2 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
B (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
B (P00918) morphogenesis of an epitheliumsearch response to pHsearch positive regulation of dipeptide transmembrane transportsearch response to zinc ionsearch bicarbonate transportsearch positive regulation of bone resorptionsearch positive regulation of synaptic transmission, GABAergicsearch positive regulation of osteoclast differentiationsearch response to steroid hormonesearch kidney developmentsearch regulation of anion transportsearch cellular response to fluid shear stresssearch regulation of intracellular pHsearch regulation of chloride transportsearch response to estrogensearch small molecule metabolic processsearch odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch secretionsearch angiotensin-activated signaling pathwaysearch response to organic substancesearch one-carbon metabolic processsearch myelin sheathsearch plasma membranesearch membranesearch cytosolsearch microvillussearch apical part of cellsearch axonsearch cytoplasmsearch extracellular spacesearch extracellular exosomesearch basolateral plasma membranesearch carbonate dehydratase activitysearch protein bindingsearch metal ion bindingsearch lyase activitysearch arylesterase activitysearch zinc ion bindingsearch

Chain InterPro annotation
B Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch