3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase Not available
Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P05093) androgen biosynthetic processsearch adrenal gland developmentsearch response to organic substancesearch progesterone metabolic processsearch cellular response to antibioticsearch response to steroid hormonesearch hippocampus developmentsearch response to methylmercurysearch steroid metabolic processsearch biphenyl metabolic processsearch response to fungicidesearch response to herbicidesearch response to nutrient levelssearch xenobiotic metabolic processsearch sterol metabolic processsearch response to gonadotropinsearch response to cAMPsearch steroid biosynthetic processsearch cellular response to gonadotropin stimulussearch sex differentiationsearch response to toxic substancesearch cellular response to lipopolysaccharidesearch oxidation-reduction processsearch dibenzo-p-dioxin metabolic processsearch positive regulation of steroid hormone biosynthetic processsearch response to organic cyclic compoundsearch hormone biosynthetic processsearch Leydig cell differentiationsearch small molecule metabolic processsearch glucocorticoid biosynthetic processsearch response to ionizing radiationsearch response to acetatesearch ovulationsearch male gonad developmentsearch phenol-containing compound metabolic processsearch organic acid metabolic processsearch response to drugsearch response to retinoic acidsearch response to cytokinesearch response to insecticidesearch phthalate metabolic processsearch neuronal cell bodysearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch axonsearch cell projectionsearch mitochondrionsearch membranesearch intracellular membrane-bounded organellesearch oxidoreductase activitysearch oxygen bindingsearch iron ion bindingsearch steroid 17-alpha-monooxygenase activitysearch monooxygenase activitysearch heme bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch 17-alpha-hydroxyprogesterone aldolase activitysearch metal ion bindingsearch lyase activitysearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch