3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Sequence family (Pfam)
A, B, C, D (P05093) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P05093) heme bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch electron carrier activitysearch iron ion bindingsearch monooxygenase activitysearch steroid 17-alpha-monooxygenase activitysearch lyase activitysearch metal ion bindingsearch oxygen bindingsearch oxidoreductase activitysearch 17-alpha-hydroxyprogesterone aldolase activitysearch oxidation-reduction processsearch response to herbicidesearch small molecule metabolic processsearch steroid metabolic processsearch biphenyl metabolic processsearch phenol-containing compound metabolic processsearch response to drugsearch male gonad developmentsearch progesterone metabolic processsearch phthalate metabolic processsearch hippocampus developmentsearch response to retinoic acidsearch xenobiotic metabolic processsearch response to cytokine stimulussearch response to steroid hormone stimulussearch response to fungicidesearch steroid biosynthetic processsearch hormone biosynthetic processsearch response to organic cyclic compoundsearch response to methylmercurysearch response to nutrient levelssearch cellular response to antibioticsearch dibenzo-p-dioxin metabolic processsearch sex differentiationsearch Leydig cell differentiationsearch cellular response to gonadotropin stimulussearch response to cAMPsearch glucocorticoid biosynthetic processsearch response to gonadotropin stimulussearch response to insecticidesearch response to acetatesearch response to organic substancesearch response to ionizing radiationsearch positive regulation of steroid hormone biosynthetic processsearch organic acid metabolic processsearch adrenal gland developmentsearch response to toxic substancesearch androgen biosynthetic processsearch cellular response to lipopolysaccharidesearch ovulationsearch sterol metabolic processsearch endoplasmic reticulum membranesearch membranesearch mitochondrionsearch endoplasmic reticulumsearch neuronal cell bodysearch axonsearch intracellular membrane-bounded organellesearch cell projectionsearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch