3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P05093) oxidation-reduction processsearch glucocorticoid biosynthetic processsearch small molecule metabolic processsearch Leydig cell differentiationsearch biphenyl metabolic processsearch response to fungicidesearch hormone biosynthetic processsearch phenol-containing compound metabolic processsearch steroid metabolic processsearch response to ionizing radiationsearch xenobiotic metabolic processsearch organic acid metabolic processsearch response to organic cyclic compoundsearch male gonad developmentsearch positive regulation of steroid hormone biosynthetic processsearch phthalate metabolic processsearch response to herbicidesearch response to drugsearch steroid biosynthetic processsearch response to methylmercurysearch androgen biosynthetic processsearch progesterone metabolic processsearch cellular response to gonadotropin stimulussearch response to toxic substancesearch response to acetatesearch response to nutrient levelssearch hippocampus developmentsearch response to cAMPsearch dibenzo-p-dioxin metabolic processsearch response to cytokinesearch response to organic substancesearch sex differentiationsearch sterol metabolic processsearch ovulationsearch response to insecticidesearch response to steroid hormonesearch response to retinoic acidsearch cellular response to lipopolysaccharidesearch response to gonadotropinsearch adrenal gland developmentsearch cellular response to antibioticsearch iron ion bindingsearch heme bindingsearch steroid 17-alpha-monooxygenase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch 17-alpha-hydroxyprogesterone aldolase activitysearch lyase activitysearch monooxygenase activitysearch oxidoreductase activitysearch oxygen bindingsearch metal ion bindingsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch mitochondrionsearch neuronal cell bodysearch membranesearch axonsearch cell projectionsearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch