3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P05093) heme bindingsearch steroid 17-alpha-monooxygenase activitysearch iron ion bindingsearch oxidoreductase activitysearch monooxygenase activitysearch metal ion bindingsearch lyase activitysearch 17-alpha-hydroxyprogesterone aldolase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch oxygen bindingsearch oxidation-reduction processsearch glucocorticoid biosynthetic processsearch response to ionizing radiationsearch response to nutrient levelssearch small molecule metabolic processsearch steroid metabolic processsearch biphenyl metabolic processsearch steroid biosynthetic processsearch hormone biosynthetic processsearch ovulationsearch male gonad developmentsearch response to insecticidesearch xenobiotic metabolic processsearch response to gonadotropinsearch cellular response to antibioticsearch cellular response to lipopolysaccharidesearch response to cytokinesearch cellular response to gonadotropin stimulussearch progesterone metabolic processsearch response to drugsearch response to acetatesearch response to steroid hormonesearch androgen biosynthetic processsearch phthalate metabolic processsearch response to methylmercurysearch sterol metabolic processsearch positive regulation of steroid hormone biosynthetic processsearch organic acid metabolic processsearch response to retinoic acidsearch hippocampus developmentsearch Leydig cell differentiationsearch response to organic substancesearch response to toxic substancesearch response to organic cyclic compoundsearch response to fungicidesearch sex differentiationsearch response to cAMPsearch dibenzo-p-dioxin metabolic processsearch response to herbicidesearch adrenal gland developmentsearch phenol-containing compound metabolic processsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch axonsearch membranesearch cell projectionsearch mitochondrionsearch neuronal cell bodysearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch