3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Sequence family (Pfam)
A, B, C, D (P05093) PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P05093) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch 17-alpha-hydroxyprogesterone aldolase activitysearch metal ion bindingsearch steroid 17-alpha-monooxygenase activitysearch lyase activitysearch heme bindingsearch iron ion bindingsearch oxidoreductase activitysearch monooxygenase activitysearch oxygen bindingsearch androgen biosynthetic processsearch glucocorticoid biosynthetic processsearch response to acetatesearch adrenal gland developmentsearch positive regulation of steroid hormone biosynthetic processsearch response to methylmercurysearch response to retinoic acidsearch response to organic substancesearch oxidation-reduction processsearch Leydig cell differentiationsearch response to toxic substancesearch organic acid metabolic processsearch response to insecticidesearch response to ionizing radiationsearch dibenzo-p-dioxin metabolic processsearch hormone biosynthetic processsearch steroid biosynthetic processsearch hippocampus developmentsearch steroid metabolic processsearch response to fungicidesearch phthalate metabolic processsearch response to organic cyclic compoundsearch response to drugsearch response to herbicidesearch small molecule metabolic processsearch response to cytokinesearch response to cAMPsearch biphenyl metabolic processsearch male gonad developmentsearch ovulationsearch xenobiotic metabolic processsearch cellular response to antibioticsearch progesterone metabolic processsearch sterol metabolic processsearch response to gonadotropinsearch response to steroid hormonesearch response to nutrient levelssearch cellular response to lipopolysaccharidesearch sex differentiationsearch cellular response to gonadotropin stimulussearch phenol-containing compound metabolic processsearch mitochondrionsearch membranesearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch neuronal cell bodysearch endoplasmic reticulumsearch cell projectionsearch axonsearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch