3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Sequence family (Pfam)
A, B, C, D (P05093) PF00067: Cytochrome P450search

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B, C, D (P05093) oxidation-reduction processsearch response to cytokinesearch cellular response to lipopolysaccharidesearch response to gonadotropinsearch hormone biosynthetic processsearch response to retinoic acidsearch male gonad developmentsearch response to methylmercurysearch cellular response to antibioticsearch steroid biosynthetic processsearch small molecule metabolic processsearch cellular response to gonadotropin stimulussearch hippocampus developmentsearch response to organic cyclic compoundsearch steroid metabolic processsearch response to fungicidesearch Leydig cell differentiationsearch adrenal gland developmentsearch sex differentiationsearch sterol metabolic processsearch biphenyl metabolic processsearch response to ionizing radiationsearch xenobiotic metabolic processsearch progesterone metabolic processsearch response to insecticidesearch ovulationsearch dibenzo-p-dioxin metabolic processsearch response to nutrient levelssearch positive regulation of steroid hormone biosynthetic processsearch phthalate metabolic processsearch glucocorticoid biosynthetic processsearch phenol-containing compound metabolic processsearch organic acid metabolic processsearch response to drugsearch response to herbicidesearch response to cAMPsearch response to organic substancesearch androgen biosynthetic processsearch response to steroid hormonesearch response to acetatesearch response to toxic substancesearch iron ion bindingsearch heme bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch lyase activitysearch steroid 17-alpha-monooxygenase activitysearch oxidoreductase activitysearch oxygen bindingsearch monooxygenase activitysearch metal ion bindingsearch 17-alpha-hydroxyprogesterone aldolase activitysearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch cell projectionsearch neuronal cell bodysearch mitochondrionsearch membranesearch axonsearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch