3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P05093) steroid 17-alpha-monooxygenase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch heme bindingsearch lyase activitysearch 17-alpha-hydroxyprogesterone aldolase activitysearch oxidoreductase activitysearch oxygen bindingsearch monooxygenase activitysearch metal ion bindingsearch iron ion bindingsearch response to cAMPsearch response to fungicidesearch steroid biosynthetic processsearch Leydig cell differentiationsearch hormone biosynthetic processsearch response to drugsearch hippocampus developmentsearch male gonad developmentsearch adrenal gland developmentsearch response to steroid hormonesearch phthalate metabolic processsearch cellular response to lipopolysaccharidesearch steroid metabolic processsearch small molecule metabolic processsearch ovulationsearch organic acid metabolic processsearch oxidation-reduction processsearch positive regulation of steroid hormone biosynthetic processsearch response to methylmercurysearch response to retinoic acidsearch progesterone metabolic processsearch xenobiotic metabolic processsearch biphenyl metabolic processsearch response to gonadotropinsearch response to organic cyclic compoundsearch sex differentiationsearch response to organic substancesearch androgen biosynthetic processsearch glucocorticoid biosynthetic processsearch response to herbicidesearch sterol metabolic processsearch response to ionizing radiationsearch dibenzo-p-dioxin metabolic processsearch response to cytokinesearch response to nutrient levelssearch response to acetatesearch cellular response to antibioticsearch phenol-containing compound metabolic processsearch response to toxic substancesearch cellular response to gonadotropin stimulussearch response to insecticidesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch axonsearch membranesearch neuronal cell bodysearch cell projectionsearch intracellular membrane-bounded organellesearch mitochondrionsearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch