3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B, C, D (P05093) monooxygenase activitysearch steroid 17-alpha-monooxygenase activitysearch iron ion bindingsearch oxidoreductase activitysearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch lyase activitysearch oxygen bindingsearch heme bindingsearch metal ion bindingsearch 17-alpha-hydroxyprogesterone aldolase activitysearch mitochondrionsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch membranesearch axonsearch cell projectionsearch neuronal cell bodysearch intracellular membrane-bounded organellesearch organic acid metabolic processsearch steroid biosynthetic processsearch androgen biosynthetic processsearch glucocorticoid biosynthetic processsearch xenobiotic metabolic processsearch sex differentiationsearch steroid metabolic processsearch male gonad developmentsearch response to herbicidesearch response to toxic substancesearch response to organic substancesearch response to acetatesearch response to ionizing radiationsearch response to organic cyclic compoundsearch sterol metabolic processsearch response to insecticidesearch biphenyl metabolic processsearch dibenzo-p-dioxin metabolic processsearch phenol-containing compound metabolic processsearch phthalate metabolic processsearch hippocampus developmentsearch adrenal gland developmentsearch ovulationsearch response to nutrient levelssearch response to retinoic acidsearch Leydig cell differentiationsearch response to cytokinesearch response to gonadotropinsearch hormone biosynthetic processsearch progesterone metabolic processsearch response to drugsearch small molecule metabolic processsearch response to steroid hormonesearch response to cAMPsearch response to methylmercurysearch oxidation-reduction processsearch response to fungicidesearch cellular response to lipopolysaccharidesearch cellular response to antibioticsearch cellular response to gonadotropin stimulussearch positive regulation of steroid hormone biosynthetic processsearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch