3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (P05093) response to drugsearch oxidation-reduction processsearch phenol-containing compound metabolic processsearch hormone biosynthetic processsearch cellular response to antibioticsearch response to gonadotropinsearch steroid metabolic processsearch male gonad developmentsearch biphenyl metabolic processsearch steroid biosynthetic processsearch response to retinoic acidsearch response to organic cyclic compoundsearch response to steroid hormonesearch small molecule metabolic processsearch Leydig cell differentiationsearch dibenzo-p-dioxin metabolic processsearch cellular response to gonadotropin stimulussearch positive regulation of steroid hormone biosynthetic processsearch cellular response to lipopolysaccharidesearch response to acetatesearch ovulationsearch response to nutrient levelssearch sex differentiationsearch hippocampus developmentsearch response to cAMPsearch xenobiotic metabolic processsearch progesterone metabolic processsearch response to fungicidesearch response to organic substancesearch phthalate metabolic processsearch response to cytokinesearch sterol metabolic processsearch response to toxic substancesearch glucocorticoid biosynthetic processsearch androgen biosynthetic processsearch response to methylmercurysearch response to herbicidesearch response to ionizing radiationsearch organic acid metabolic processsearch adrenal gland developmentsearch response to insecticidesearch membranesearch mitochondrionsearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch neuronal cell bodysearch cell projectionsearch intracellular membrane-bounded organellesearch axonsearch oxidoreductase activitysearch steroid 17-alpha-monooxygenase activitysearch monooxygenase activitysearch oxygen bindingsearch metal ion bindingsearch heme bindingsearch oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch iron ion bindingsearch 17-alpha-hydroxyprogesterone aldolase activitysearch lyase activitysearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch