3ruk Summary


Human Cytochrome P450 CYP17A1 in complex with Abiraterone

The structure was published by Devore, N.M. and Scott, E.E., in 2012 in a paper entitled "Structures of cytochrome P450 17A1 with prostate cancer drugs abiraterone and TOK-001." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Steroid 17-alpha-hydroxylase/17,20 lyase.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
B Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
C Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%
D Steroid 17-alpha-hydroxylase/17,20 lyase P05093 (24-508) (CP17A_HUMAN)search Homo sapienssearch 95% 494 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P05093 (24 - 508) Steroid 17-alpha-hydroxylase/17,20 lyase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (P05093) Cytochrome p450search PF00067: Cytochrome P450search

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B, C, D (P05093) oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygensearch steroid 17-alpha-monooxygenase activitysearch lyase activitysearch iron ion bindingsearch heme bindingsearch oxidoreductase activitysearch oxygen bindingsearch monooxygenase activitysearch 17-alpha-hydroxyprogesterone aldolase activitysearch metal ion bindingsearch oxidation-reduction processsearch response to fungicidesearch response to organic cyclic compoundsearch hippocampus developmentsearch cellular response to lipopolysaccharidesearch hormone biosynthetic processsearch response to gonadotropinsearch steroid metabolic processsearch response to methylmercurysearch response to toxic substancesearch response to steroid hormonesearch phthalate metabolic processsearch response to cytokinesearch response to drugsearch response to cAMPsearch cellular response to gonadotropin stimulussearch small molecule metabolic processsearch response to ionizing radiationsearch male gonad developmentsearch phenol-containing compound metabolic processsearch steroid biosynthetic processsearch response to nutrient levelssearch response to retinoic acidsearch cellular response to antibioticsearch progesterone metabolic processsearch xenobiotic metabolic processsearch dibenzo-p-dioxin metabolic processsearch positive regulation of steroid hormone biosynthetic processsearch sex differentiationsearch Leydig cell differentiationsearch glucocorticoid biosynthetic processsearch response to insecticidesearch organic acid metabolic processsearch sterol metabolic processsearch response to herbicidesearch adrenal gland developmentsearch biphenyl metabolic processsearch androgen biosynthetic processsearch response to acetatesearch ovulationsearch response to organic substancesearch neuronal cell bodysearch membranesearch endoplasmic reticulumsearch endoplasmic reticulum membranesearch axonsearch cell projectionsearch mitochondrionsearch intracellular membrane-bounded organellesearch

Chain InterPro annotation
A, B, C, D Cytochrome P450search Cytochrome P450, E-class, group Isearch Cytochrome P450, conserved sitesearch