3rps Summary


Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol

The structure was published by Bischoff, N., Raaf, J., Olsen, B., Bretner, M., Issinger, O.G., and Niefind, K., in 2011 in a paper entitled "Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha'" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Casein kinase II subunit alpha.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Casein kinase II subunit alpha P68400 (1-335) (CSK21_HUMAN)search Homo sapienssearch 100% 335 99%
B Casein kinase II subunit alpha P68400 (1-335) (CSK21_HUMAN)search Homo sapienssearch 100% 335 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P68400 (1 - 335) Casein kinase II subunit alpha Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P68400) Transferase(Phosphotransferase) domain 1search, Phosphorylase Kinase; domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A, B (P68400) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch