3ro2 Summary


Structures of the LGN/NuMA complex

The structure was published by Zhu, J., Wen, W., Zheng, Z., et al., Du, Q., Wang, W., and Zhang, M., in 2011 in a paper entitled "LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.3 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely G-protein-signaling modulator 2 and peptide of Nuclear mitotic apparatus protein 1.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A G-protein-signaling modulator 2 Q8VDU0 (22-357) (GPSM2_MOUSE)search Mus musculussearch < 90% 338 97%
B peptide of Nuclear mitotic apparatus protein 1 Q14980 (1899-1926) (NUMA1_HUMAN)search Homo sapienssearch < 90% 28 78%

This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
Q8VDU0 (22 - 357) G-protein-signaling modulator 2 Mus musculus
Q14980 (1899 - 1926) peptide of Nuclear mitotic apparatus protein 1 Homo sapiens

Chain Sequence family (Pfam)
A Tetratricopeptide repeatsearch

Chain ID Biological process (GO) Molecular function (GO)
A (Q8VDU0) regulation of G-protein coupled receptor protein signaling pathwaysearch GDP-dissociation inhibitor activitysearch

Chain InterPro annotation
A Tetratricopeptide TPR1search Tetratricopeptide-like helical domainsearch Tetratricopeptide repeat-containing domainsearch Tetratricopeptide repeatsearch G-protein-signalling modulator 1search