3rj7 Summary

pdbe.org/3rj7
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Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide

The structure was published by Can, D., Spingler, B., Schmutz, P., et al., Santos, I., Supuran, C.T., and Alberto, R., in 2012 in a paper entitled "[(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 96% 258 100%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A (P00918) Carbonic Anhydrase IIsearch PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A (P00918) zinc ion bindingsearch carbonate dehydratase activitysearch metal ion bindingsearch protein bindingsearch lyase activitysearch arylesterase activitysearch positive regulation of osteoclast differentiationsearch positive regulation of dipeptide transmembrane transportsearch response to pHsearch response to steroid hormonesearch bicarbonate transportsearch response to organic substancesearch positive regulation of cellular pH reductionsearch angiotensin-activated signaling pathwaysearch morphogenesis of an epitheliumsearch small molecule metabolic processsearch response to estrogensearch odontogenesis of dentin-containing toothsearch positive regulation of synaptic transmission, GABAergicsearch regulation of intracellular pHsearch kidney developmentsearch positive regulation of bone resorptionsearch regulation of anion transportsearch secretionsearch regulation of chloride transportsearch cellular response to fluid shear stresssearch response to zinc ionsearch one-carbon metabolic processsearch axonsearch cytosolsearch cytoplasmsearch myelin sheathsearch plasma membranesearch microvillussearch extracellular exosomesearch basolateral plasma membranesearch extracellular spacesearch apical part of cellsearch membranesearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch