3rj7 Summary


Human carbonic anhydrase II complexed with its inhibitor rhenium(I)triscarbonyl-cyclopentadienyl-carboxy-4-aminomethylbenzene-sulfonamide

The structure was published by Can, D., Spingler, B., Schmutz, P., et al., Santos, I., Supuran, C.T., and Alberto, R., in 2012 in a paper entitled "[(Cp-R)M(CO)(3) ] (M=Re or (99m) Tc) Arylsulfonamide, Arylsulfamide, and Arylsulfamate Conjugates for Selective Targeting of Human Carbonic Anhydrase IX." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.2 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 258 residues which is 99% of the natural sequence. Out of 258 residues 257 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (3-260) (CAH2_HUMAN)search Homo sapienssearch 98% 258 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (3 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A (P00918) odontogenesis of dentin-containing toothsearch positive regulation of cellular pH reductionsearch bicarbonate transportsearch response to estrogensearch regulation of intracellular pHsearch response to steroid hormonesearch one-carbon metabolic processsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of osteoclast differentiationsearch morphogenesis of an epitheliumsearch response to organic substancesearch response to zinc ionsearch small molecule metabolic processsearch regulation of chloride transportsearch kidney developmentsearch angiotensin-activated signaling pathwaysearch positive regulation of synaptic transmission, GABAergicsearch response to pHsearch positive regulation of bone resorptionsearch secretionsearch regulation of anion transportsearch apical part of cellsearch axonsearch extracellular vesicular exosomesearch extracellular spacesearch cytoplasmsearch plasma membranesearch microvillussearch cytosolsearch membranesearch basolateral plasma membranesearch myelin sheathsearch carbonate dehydratase activitysearch lyase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch