3rg3 Summary

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Crystal structure of the W5E mutant of human carbonic anhydrase II

The structure was published by Mikulski, R., Domsic, J.F., Ling, G., et al., Robbins, A.H., Silverman, D.N., and McKenna, R., in 2011 in a paper entitled "Structure and catalysis by carbonic anhydrase II: role of active-site tryptophan 5." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.903 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Carbonic anhydrase 2. This molecule has the UniProt identifier P00918 (CAH2_HUMAN)search. The sample contained 260 residues which is 100% of the natural sequence. Out of 260 residues 255 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Carbonic anhydrase 2 P00918 (1-260) (CAH2_HUMAN)search Homo sapienssearch 98% 260 98%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P00918 (1 - 260) Carbonic anhydrase 2 Homo sapiens

Chain Sequence family (Pfam)
A (P00918) PF00194: Eukaryotic-type carbonic anhydrasesearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (P00918) carbonate dehydratase activitysearch zinc ion bindingsearch metal ion bindingsearch protein bindingsearch lyase activitysearch extracellular spacesearch plasma membranesearch cytosolsearch apical part of cellsearch cytoplasmsearch extracellular vesicular exosomesearch basolateral plasma membranesearch microvillussearch membranesearch axonsearch bicarbonate transportsearch angiotensin-activated signaling pathwaysearch regulation of intracellular pHsearch regulation of anion transportsearch odontogenesis of dentin-containing toothsearch positive regulation of dipeptide transmembrane transportsearch positive regulation of cellular pH reductionsearch response to steroid hormonesearch carbon dioxide transportsearch secretionsearch response to organic substancesearch positive regulation of osteoclast differentiationsearch response to estrogensearch morphogenesis of an epitheliumsearch response to pHsearch small molecule metabolic processsearch kidney developmentsearch response to zinc ionsearch positive regulation of bone resorptionsearch one-carbon metabolic processsearch

Chain InterPro annotation
A Alpha carbonic anhydrasesearch Carbonic anhydrase, alpha-class, conserved sitesearch Carbonic anhydrase 2search Carbonic anhydrase, alpha-classsearch