3rf3 Summary

pdbe.org/3rf3
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Shigella IpaA-VBS3 in complex with human vinculin

The structure was published by Park, H., Valencia-Gallardo, C., Sharff, A., Tran Van Nhieu, G., and Izard, T., in 2011 in a paper entitled "Novel vinculin binding site of the IpaA invasin of Shigella." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.61 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Vinculin and Invasin ipaA.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Vinculin P18206 (1-258) (VINC_HUMAN)search Homo sapienssearch 94% 258 100%
B Vinculin P18206 (1-258) (VINC_HUMAN)search Homo sapienssearch 94% 258 100%
C Invasin ipaA P18010 (488-512) (IPAA_SHIFL)search Shigella flexnerisearch < 90% 29 82%
D Invasin ipaA P18010 (488-512) (IPAA_SHIFL)search Shigella flexnerisearch < 90% 29 82%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P18206 (1 - 258) Vinculin Homo sapiens
P18010 (488 - 512) Invasin ipaA Shigella flexneri

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P18206) vbs2 fragment of talinsearch, Four Helix Bundle (Hemerythrin (Met), subunit A)search PF01044: Vinculin familysearch
C, D Salmonella invasion protein Asearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P18206) structural molecule activitysearch actin cytoskeletonsearch cell adhesionsearch

Chain InterPro annotation
A, B Vinculin, conserved sitesearch Vinculin/alpha-cateninsearch
C, D