› 3rep

X-ray diffraction
1.8Å resolution

Crystal structure of the ILK/alpha-parvin core complex (MnATP)

Released:
DOI: 10.2210/pdb3rep/pdb
PDB entry 3rep coloured by chain, front view.
PDB entry 3rep coloured by chain, side view.
PDB entry 3rep coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Fukuda K, Qin J

Function and Biology Details

Reaction catalysed: 
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-171669 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Integrin-linked protein kinase Chain: A
Molecule details ›
Chain: A
Length: 271 amino acids
Theoretical weight: 30.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13418 (Residues: 182-452; Coverage: 60%)
Gene names: ILK, ILK1, ILK2
Sequence domains: Protein tyrosine and serine/threonine kinase
Structure domains:
Alpha-parvin Chain: B
Molecule details ›
Chain: B
Length: 129 amino acids
Theoretical weight: 14.84 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NVD7 (Residues: 248-372; Coverage: 34%)
Gene names: MXRA2, PARVA
Sequence domains: Calponin homology (CH) domain
Structure domains: Calponin-like domain

Ligands and Environments

2 bound ligands:
Ligand MN 1 x MN
Ligand ATP 1 x ATP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU MICROMAX-007 HF
Spacegroup: P21
Unit cell:
a: 44.022Å b: 116.28Å c: 47.284Å
α: 90° β: 101.53° γ: 90°
R-values:
R R work R free
0.206 0.204 0.238
Expression system: Escherichia coli BL21(DE3)

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