MK2 kinase bound to Compound 1
The structure was published by Barf, T., Kaptein, A., Wilde, S., et al., Hofstra, C., Hornberg, J., and Oubrie, A., in 2011 in a paper entitled "Structure-based lead identification of ATP-competitive MK2 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.0 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of MAP kinase-activated protein kinase 2. This molecule has the UniProt identifier P49137 (MAPK2_HUMAN). The sample contained 319 residues which is < 90% of the natural sequence. Out of 319 residues 253 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: