3r2x Summary

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Crystal structure of the de novo designed binding protein HB36.3 in complex the the 1918 influenza virus hemagglutinin

The structure was published by Fleishman, S.J., Whitehead, T.A., Ekiert, D.C., et al., Strauch, E.M., Wilson, I.A., and Baker, D., in 2011 in a paper entitled "Computational design of proteins targeting the conserved stem region of influenza hemagglutinin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Hemagglutinin and HB36.3, designed hemagglutinin binding protein.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms heterononamer.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Hemagglutinin Q9WFX3 (18-344) (HEMA_I18A0)search Influenza A virus (A/Brevig Mission/1/1918(H1N1))search < 90% 331 97%
B Hemagglutinin Q9WFX3 (345-520) (HEMA_I18A0)search Influenza A virus (A/Brevig Mission/1/1918(H1N1))search < 90% 179 95%
C HB36.3, designed hemagglutinin binding protein Not available
synthetic constructsearch Not available 93 88%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9WFX3 (18 - 344) Hemagglutinin Influenza A virus (A/Brevig Mission/1/1918(H1N1))

Chain Structural classification (CATH) Sequence family (Pfam)
A Haemagglutininsearch
B Hemagglutinin Ectodomain; Chain Bsearch Haemagglutininsearch
C Hypothetical protein - apc36109-like domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A (Q9WFX3) viral envelopesearch fusion of virus membrane with host plasma membranesearch host cell surface receptor bindingsearch
B (Q9WFX3) viral envelopesearch fusion of virus membrane with host plasma membranesearch host cell surface receptor bindingsearch

Chain InterPro annotation
A Haemagglutinin, influenzavirus Asearch Haemagglutinin, influenzavirus A/Bsearch Viral capsid/haemagglutinin proteinsearch Haemagglutinin, HA1 chain, beta-ribbon domainsearch Haemagglutinin, HA1 chain, alpha/beta domainsearch
B Haemagglutinin, influenzavirus Bsearch Haemagglutinin, influenzavirus A/Bsearch Haemagglutinin, stalksearch
C Protein of unknown function DUF1871search Apc36109-like domainsearch