3r2b Summary

pdbe.org/3r2b
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MK2 kinase bound to Compound 5b

The structure was published by Barf, T., Kaptein, A., Wilde, S., et al., Hofstra, C., Hornberg, J., and Oubrie, A., in 2011 in a paper entitled "Structure-based lead identification of ATP-competitive MK2 inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.9 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of MAP kinase-activated protein kinase 2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
B MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
C MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
D MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
E MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
F MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
G MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
H MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
I MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
J MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
K MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%
L MAP kinase-activated protein kinase 2 P49137 (47-364) (MAPK2_HUMAN)search Homo sapienssearch 100% 318 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49137 (47 - 364) MAP kinase-activated protein kinase 2 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B, C, D, E, F, G, H, I, J, K, L (P49137) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch
Chain InterPro annotation
A, B, C, D, E, F, G, H, I, J, K, L Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch MAP kinase activated protein kinase, C-terminal domainsearch