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MK2 kinase bound to Compound 5b

X-ray diffraction
2.9Å resolution
PDB entry 3r2b coloured by chain, front view.
PDB entry 3r2b coloured by chain, side view.
PDB entry 3r2b coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14648.66 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 10
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14877.28 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 11
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14984.76 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 12
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 15054.42 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 2
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14604.85 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 3
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14858.93 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 4
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14769.93 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 5
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14977.75 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 6
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14797.56 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 7
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14947.34 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 8
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14895.28 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865
Assembly 9
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Assembly Name: MAP kinase-activated protein kinase 2
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Multimeric state: monomeric
Accessible surface area: 14967.4 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-155865

Macromolecules

MAP kinase-activated protein kinase 2
Chains: A, B, C, D, E, F, G, H, I, J, K, L
Length: 318 amino acids
Theoretical weight: 36.75 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P49137 (Residues: 47-364; Coverage: 80%)
Gene name: MAPKAPK2
Pfam: Protein kinase domain
InterPro:
CATH:
MAP kinase-activated protein kinase 2 in PDB entry 3r2b, assembly 1, front view.
MAP kinase-activated protein kinase 2 in PDB entry 3r2b, assembly 1, side view.
MAP kinase-activated protein kinase 2 in PDB entry 3r2b, assembly 1, top view.
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