The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
The structure was published by Xiang, Y., Hirth, B., Asmussen, G., et al., Skerlj, R., Stepp, J.D., and Wei, R.R., in 2011 in a paper entitled "The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.95 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN). The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 271 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: