3r00 Summary

pdbe.org/3r00
spacer

The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors

The structure was published by Xiang, Y., Hirth, B., Asmussen, G., et al., Skerlj, R., Stepp, J.D., and Wei, R.R., in 2011 in a paper entitled "The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.1 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Proto-oncogene serine/threonine-protein kinase pim-1. This molecule has the UniProt identifier P11309 (PIM1_HUMAN)search. The sample contained 299 residues which is < 90% of the natural sequence. Out of 299 residues 274 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Proto-oncogene serine/threonine-protein kinase pim-1 P11309 (120-404) (PIM1_HUMAN)search Homo sapienssearch < 90% 299 91%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P11309 (120 - 404) Proto-oncogene serine/threonine-protein kinase pim-1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO)
A (P11309) ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein serine/threonine kinase activitysearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch