› 3qpn

X-ray diffraction
2Å resolution

Function and Biology Details

Reaction catalysed: 
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-193052 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A Chain: A
Molecule details ›
Chain: A
Length: 362 amino acids
Theoretical weight: 41.66 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q9QYJ6 (Residues: 452-794; Coverage: 43%)
Gene name: Pde10a
Sequence domains: 3'5'-cyclic nucleotide phosphodiesterase
Structure domains: 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Ligands and Environments

4 bound ligands:
Ligand SO4 1 x SO4
Ligand ZN 1 x ZN
Ligand MG 1 x MG
Ligand PFK 1 x PFK
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E SUPERBRIGHT
Spacegroup: R3
Unit cell:
a: 120.672Å b: 120.672Å c: 82.647Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.216 0.214 0.24
Expression system: Spodoptera frugiperda

Quick links

Citations

1 review citation

Advances in targeting cyclic nucleotide phosphodiesterases.
Maurice et al. (2014)
12 other articles

1 mention without citation

Structure-Based Design, Synthesis, Biological Evaluation, and Molecular Docking of Novel PDE10 Inhibitors With Antioxidant Activities.
Li et al. (2018)