3qla Summary

pdbe.org/3qla
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Hexagonal complex structure of ATRX ADD bound to H3K9me3 peptide

The structure was published by Iwase, S., Xiang, B., Ghosh, S., et al., Patel, D.J., Li, H., and Shi, Y., in 2011 in a paper entitled "ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.6 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 2 biomacromolecules, namely Transcriptional regulator ATRX and peptide of Histone H3.3.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Transcriptional regulator ATRX P46100 (167-289) (ATRX_HUMAN)search Homo sapienssearch < 90% 129 98%
D Transcriptional regulator ATRX P46100 (167-289) (ATRX_HUMAN)search Homo sapienssearch < 90% 129 98%
C peptide of Histone H3.3 P84243 (2-16) (H33_HUMAN)search Homo sapienssearch 99% 15 66%
F peptide of Histone H3.3 P84243 (2-16) (H33_HUMAN)search Homo sapienssearch 99% 15 66%


This entry contains 2 unique UniProt proteins:

UniProt accession Name Organism PDB
P46100 (167 - 289) Transcriptional regulator ATRX Homo sapiens
P84243 (2 - 16) peptide of Histone H3.3 Homo sapiens
Chain InterPro annotation
A, D Zinc finger, RING-typesearch Zinc finger, FYVE/PHD-typesearch Zinc finger, RING/FYVE/PHD-typesearch ADD domainsearch
C, F