Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
The structure was published by Medina, J.R., Becker, C.J., Blackledge, C.W., et al., Campobasso, N., Ward, P., and Axten, J.M., in 2011 in a paper entitled "Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of 3-phosphoinositide-dependent protein kinase 1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN). The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 271 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: