3qd0 Summary


Phosphoinositide-Dependent Kinase-1 (PDK1) kinase domain with (2R,5S)-1-[2-Amino-6-(3-amino-1H-indazol-6-yl)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

The structure was published by Medina, J.R., Becker, C.J., Blackledge, C.W., et al., Campobasso, N., Ward, P., and Axten, J.M., in 2011 in a paper entitled "Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.99 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of 3-phosphoinositide-dependent protein kinase 1. This molecule has the UniProt identifier O15530 (PDPK1_HUMAN)search. The sample contained 312 residues which is < 90% of the natural sequence. Out of 312 residues 271 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A 3-phosphoinositide-dependent protein kinase 1 O15530 (48-359) (PDPK1_HUMAN)search Homo sapienssearch < 90% 312 87%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
O15530 (48 - 359) 3-phosphoinositide-dependent protein kinase 1 Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO)
A (O15530) protein phosphorylationsearch protein serine/threonine kinase activitysearch ATP bindingsearch protein kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch

Chain InterPro annotation
A Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch