3qcg Summary


Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid

The structure was published by Sheriff, S., Beno, B.R., Zhai, W., et al., Westphal, R.S., O'Connell, J., and Gerritz, S.W., in 2011 in a paper entitled "Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Receptor-type tyrosine-protein phosphatase gamma. This molecule has the UniProt identifier P23470 (PTPRG_HUMAN)search. The sample contained 310 residues which is < 90% of the natural sequence. Out of 310 residues 281 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Receptor-type tyrosine-protein phosphatase gamma P23470 (825-1128) (PTPRG_HUMAN)search Homo sapienssearch < 90% 310 92%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P23470 (825 - 1128) Receptor-type tyrosine-protein phosphatase gamma Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Protein tyrosine phosphatase superfamilysearch Protein-tyrosine phosphatasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (P23470) protein tyrosine phosphatase activitysearch phosphatase activitysearch dephosphorylationsearch protein dephosphorylationsearch

Chain InterPro annotation
A Protein-tyrosine phosphatase, receptor/non-receptor typesearch Protein-tyrosine/Dual specificity phosphatasesearch Protein-tyrosine phosphatase, active sitesearch Protein-tyrosine phosphatase-likesearch