Human receptor protein tyrosine phosphatase gamma, domain 1, in complex with 3-[(3-bromo-4-chlorobenzyl)sulfanyl]thiophene-2-carboxylic acid
The structure was published by Sheriff, S., Beno, B.R., Zhai, W., et al., Westphal, R.S., O'Connell, J., and Gerritz, S.W., in 2011 in a paper entitled "Small molecule receptor protein tyrosine phosphatase [gamma](RPTP[gamma]) ligands that inhibit phosphatase activity via perturbation of the tryptophan-proline-aspartate (WPD) loop" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.05 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Receptor-type tyrosine-protein phosphatase gamma. This molecule has the UniProt identifier P23470 (PTPRG_HUMAN). The sample contained 310 residues which is < 90% of the natural sequence. Out of 310 residues 281 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: