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Crystal structure of fumarase Fum from Mycobacterium marinum

Source organism: Mycobacterium marinum M
Biochemical function: lyase activity
Biological process: fumarate metabolic process
Cellular component: tricarboxylic acid cycle heteromeric enzyme complex

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EC 4.2.1.2: Fumarate hydratase

Reaction catalysed:
(S)-malate = fumarate + H(2)O
Systematic name:
(S)-malate hydro-lyase (fumarate-forming)
Alternative Name(s):
  • (S)-malate hydro-lyase
  • Fumarase
  • L-malate hydro-lyase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF10415
Domain description: Fumarase C C-terminus
Occurring in:
  1. Fumarate hydratase class II
The deposited structure of PDB entry 3qbp contains 4 copies of Pfam domain PF10415 (Fumarase C C-terminus) in Fumarate hydratase class II. Showing 1 copy in chain B.

PF00206
Domain description: Lyase
Occurring in:
  1. Fumarate hydratase class II
The deposited structure of PDB entry 3qbp contains 4 copies of Pfam domain PF00206 (Lyase) in Fumarate hydratase class II. Showing 1 copy in chain B.

InterPro InterPro annotations
IPR000362
Domain description: Fumarate lyase family
Occurring in:
  1. Fumarate hydratase class II
IPR005677
Domain description: Fumarate hydratase, class II
Occurring in:
  1. Fumarate hydratase class II
IPR018951
Domain description: Fumarase C, C-terminal
Occurring in:
  1. Fumarate hydratase class II
IPR020557
Domain description: Fumarate lyase, conserved site
Occurring in:
  1. Fumarate hydratase class II
IPR022761
Domain description: Fumarate lyase, N-terminal
Occurring in:
  1. Fumarate hydratase class II
IPR024083
Domain description: Fumarase/histidase, N-terminal
Occurring in:
  1. Fumarate hydratase class II
IPR008948
Domain description: L-Aspartase-like
Occurring in:
  1. Fumarate hydratase class II

Structure domains

CATH CATH domains
1.10.40.30
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Ribonucleotide Reductase Protein R1; domain 1
Homology: Fumarase/aspartase (C-terminal domain)
Occurring in:
  1. Fumarate hydratase class II
The deposited structure of PDB entry 3qbp contains 4 copies of CATH domain 1.10.40.30 (Ribonucleotide Reductase Protein R1; domain 1) in Fumarate hydratase class II. Showing 1 copy in chain B.
1.20.200.10
Class: Mainly Alpha
Architecture: Up-down Bundle
Topology: Fumarase C; Chain A, domain 2
Homology: Fumarase/aspartase (Central domain)
Occurring in:
  1. Fumarate hydratase class II
The deposited structure of PDB entry 3qbp contains 4 copies of CATH domain 1.20.200.10 (Fumarase C; Chain A, domain 2) in Fumarate hydratase class II. Showing 1 copy in chain B.
1.10.275.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Fumarase C; Chain B, domain 1
Homology: Fumarase/aspartase (N-terminal domain)
Occurring in:
  1. Fumarate hydratase class II
The deposited structure of PDB entry 3qbp contains 4 copies of CATH domain 1.10.275.10 (Fumarase C; Chain B, domain 1) in Fumarate hydratase class II. Showing 1 copy in chain B.

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