3qag Summary


Human Glutathione Transferase O2 with glutathione -new crystal form

The structure was published by Zhou, H., Brock, J., Liu, D., Board, P.G., and Oakley, A.J., in 2012 in a paper entitled "Structural insights into the dehydroascorbate reductase activity of human omega-class glutathione transferases." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2011.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Glutathione S-transferase omega-2. This molecule has the UniProt identifier Q9H4Y5 (GSTO2_HUMAN)search. The sample contained 239 residues which is 98% of the natural sequence. Out of 239 residues 238 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glutathione S-transferase omega-2 Q9H4Y5 (1-239) (GSTO2_HUMAN)search Homo sapienssearch 98% 239 99%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q9H4Y5 (1 - 239) Glutathione S-transferase omega-2 Homo sapiens

Chain Sequence family (Pfam)
A (Q9H4Y5) PF13410: Glutathione S-transferase, C-terminal domainsearch, PF13417: Glutathione S-transferase, N-terminal domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A (Q9H4Y5) glutathione transferase activitysearch methylarsonate reductase activitysearch glutathione dehydrogenase (ascorbate) activitysearch oxidoreductase activitysearch transferase activitysearch cytoplasmsearch cytosolsearch extracellular vesicular exosomesearch L-ascorbic acid metabolic processsearch xenobiotic metabolic processsearch small molecule metabolic processsearch water-soluble vitamin metabolic processsearch metabolic processsearch glutathione derivative biosynthetic processsearch oxidation-reduction processsearch vitamin metabolic processsearch cellular response to arsenic-containing substancesearch

Chain InterPro annotation
A Glutathione S-transferase, N-terminalsearch Glutathione S-transferase, omega-classsearch Glutathione S-transferase, C-terminal-likesearch Thioredoxin-like foldsearch