B-Raf kinase domain in complex with a tetrahydronaphthalene inhibitor
The structure was published by Gould, A.E., Adams, R., Adhikari, S., et al., Zhang, D.M., Zhang, Q., and Galvin, K.M., in 2011 in a paper entitled "Design and optimization of potent and orally bioavailable tetrahydronaphthalene raf inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 3.1 Å and deposited in 2011.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase B-raf.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: