3q4t Summary


Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin

The structure was published by Horbelt, D., Boergermann, J.H., Chaikuad, A., et al., Timmel, T., Bullock, A.N., and Knaus, P., in 2015 in a paper entitled "Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.96 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Activin receptor type-2A.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Activin receptor type-2A P27037 (191-488) (AVR2A_HUMAN)search Homo sapienssearch < 90% 322 95%
B Activin receptor type-2A P27037 (191-488) (AVR2A_HUMAN)search Homo sapienssearch < 90% 322 95%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P27037 (191 - 488) Activin receptor type-2A Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein kinase domainsearch

Chain ID Molecular function (GO) Cellular component (GO) Biological process (GO)
A, B (P27037) ATP bindingsearch protein kinase activitysearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch receptor signaling protein serine/threonine kinase activitysearch membranesearch protein phosphorylationsearch transmembrane receptor protein serine/threonine kinase signaling pathwaysearch regulation of signal transductionsearch

Chain InterPro annotation
A, B Ser/Thr protein kinase, TGFB receptorsearch Protein kinase domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch