Crystal structure of Activin receptor type-IIA (ACVR2A) kinase domain in complex with dorsomorphin
The structure was published by Horbelt, D., Boergermann, J.H., Chaikuad, A., et al., Timmel, T., Bullock, A.N., and Knaus, P., in 2015 in a paper entitled "Small Molecules Dorsomorphin and LDN-193189 Inhibit Myostatin/GDF8 Signaling and Promote Functional Myoblast Differentiation." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 1.96 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Activin receptor type-2A.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: