3q4c Summary

pdbe.org/3q4c
spacer

Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292

The structure was published by Xie, P., Streu, C., Qin, J., et al., Pagano, N., Meggers, E., and Marmorstein, R., in 2009 in a paper entitled "The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 3.2 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Serine/threonine-protein kinase B-raf.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Serine/threonine-protein kinase B-raf P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 85%
B Serine/threonine-protein kinase B-raf P15056 (432-726) (BRAF_HUMAN)search Homo sapienssearch < 90% 307 85%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P15056 (432 - 726) Serine/threonine-protein kinase B-raf Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Biological process (GO) Molecular function (GO)
A, B (P15056) protein phosphorylationsearch transferase activity, transferring phosphorus-containing groupssearch ATP bindingsearch protein serine/threonine kinase activitysearch protein kinase activitysearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch