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Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292

X-ray diffraction
3.2Å resolution
PDB entry 3q4c coloured by chain, front view.
PDB entry 3q4c coloured by chain, side view.
PDB entry 3q4c coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Serine/threonine-protein kinase B-raf
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Multimeric state: monomeric
Accessible surface area: 13568.28 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147194
Assembly 2
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Assembly Name: Serine/threonine-protein kinase B-raf
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Multimeric state: monomeric
Accessible surface area: 13505.9 Å2
Buried surface area: 0.0 Å2
Dissociation area: 0 Å2
Dissociation energy (ΔGdiss): 0 kcal/mol
Dissociation entropy (TΔSdiss): 0 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-147194

Macromolecules

Serine/threonine-protein kinase B-raf
Chains: A, B
Length: 307 amino acids
Theoretical weight: 35.22 KDa
Source organism: Homo sapiens
Expression system: unidentified baculovirus
UniProt:
  • Canonical: P15056 (Residues: 432-726; Coverage: 39%)
Gene names: BRAF, BRAF1, RAFB1
Pfam: Protein tyrosine and serine/threonine kinase
InterPro:
CATH:
Serine/threonine-protein kinase B-raf in PDB entry 3q4c, assembly 1, front view.
Serine/threonine-protein kinase B-raf in PDB entry 3q4c, assembly 1, side view.
Serine/threonine-protein kinase B-raf in PDB entry 3q4c, assembly 1, top view.
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