Structure of Janus kinase 2 with a pyrrolotriazine inhibitor
The structure was published by Harikrishnan, L.S., Kamau, M.G., Wan, H., et al., Khan, J., Sack, J.S., and Purandare, A.V., in 2011 in a paper entitled "Pyrrolo[1,2-f]triazines as JAK2 inhibitors: Achieving potency and selectivity for JAK2 over JAK3." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains multiple copies of the structure of Tyrosine-protein kinase JAK2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: