Human Squalene synthase in complex with (2R,3R)-2-Carboxymethoxy-3-[5-(2-naphthalenyl)pentyl]aminocarbonyl-3-[5-(2-naphthalenyl)pentyloxy]propionic acid
The structure was published by Ichikawa, M., Yokomizo, A., Itoh, M., et al., Suzuki, M., Terayama, K., and Kanda, A., in 2011 in a paper entitled "Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors" (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
The PDB entry contains the structure of Squalene synthase. This molecule has the UniProt identifier P37268 (FDFT_HUMAN). The sample contained 340 residues which is < 90% of the natural sequence. Out of 340 residues 326 were observed and are deposited in the PDB.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule is most likely monomeric.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 1 unique UniProt protein: