3q30 Summary


Human Squalene synthase in complex with (2R,3R)-2-Carboxymethoxy-3-[5-(2-naphthalenyl)pentyl]aminocarbonyl-3-[5-(2-naphthalenyl)pentyloxy]propionic acid

The structure was published by Ichikawa, M., Yokomizo, A., Itoh, M., et al., Suzuki, M., Terayama, K., and Kanda, A., in 2011 in a paper entitled "Discovery of a new 2-aminobenzhydrol template for highly potent squalene synthase inhibitors" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.0 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Squalene synthase. This molecule has the UniProt identifier P37268 (FDFT_HUMAN)search. The sample contained 340 residues which is < 90% of the natural sequence. Out of 340 residues 326 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Squalene synthase P37268 (31-370) (FDFT_HUMAN)search Homo sapienssearch < 90% 340 97%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P37268 (31 - 370) Squalene synthase Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Farnesyl Diphosphate Synthasesearch Squalene/phytoene synthasesearch

Chain ID Cellular component (GO) Molecular function (GO) Biological process (GO)
A (P37268) integral component of membranesearch transferase activitysearch farnesyl-diphosphate farnesyltransferase activitysearch transferase activity, transferring alkyl or aryl (other than methyl) groupssearch biosynthetic processsearch lipid biosynthetic processsearch

Chain InterPro annotation
A Squalene/phytoene synthasesearch Farnesyl-diphosphate farnesyltransferasesearch Isoprenoid synthase domainsearch Squalene/phytoene synthase, conserved sitesearch