3q27 Summary


Cyrstal structure of human alpha-synuclein (32-57) fused to maltose binding protein (MBP)

The structure was published by Zhao, M., Cascio, D., Sawaya, M.R., and Eisenberg, D., in 2011 in a paper entitled "Structures of segments of alpha-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 1.302 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Maltose-binding periplasmic protein/alpha-synuclein chimeric protein. This molecule has the UniProt identifier P0AEX9 (MALE_ECOLI)search. The sample contained 397 residues which is 99% of the natural sequence. Out of 397 residues 385 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Maltose-binding periplasmic protein/alpha-synuclein chimeric protein P0AEX9 (27-392) (MALE_ECOLI)search ,
P37840 (32-57) (SYUA_HUMAN)search
Escherichia coli K-12search ,
Homo sapienssearch
96% ,
397 98%

Chain Structural classification (CATH) Sequence family (Pfam)
A (P37840) Periplasmic binding protein-like IIsearch PF01387: Synucleinsearch
A (P0AEX9) Periplasmic binding protein-like IIsearch PF01547: Bacterial extracellular solute-binding proteinsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A (P0AEX9P37840) transportsearch carbohydrate transportsearch maltose transportsearch cellular response to DNA damage stimulussearch detection of maltose stimulussearch cell chemotaxissearch maltodextrin transportsearch transporter activitysearch maltose transmembrane transporter activitysearch protein bindingsearch maltose bindingsearch maltose transport complexsearch ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containingsearch periplasmic spacesearch ATP-binding cassette (ABC) transporter complexsearch outer membrane-bounded periplasmic spacesearch

Chain InterPro annotation
A Synucleinsearch Solute-binding family 1search Maltose binding proteinsearch Solute-binding family 1, conserved sitesearch