Bovine GRK2 in complex with Gbetagamma subunits and a selective kinase inhibitor (CMPD101)
The structure was published by Thal, D.M., Yeow, R.Y., Schoenau, C., Huber, J., and Tesmer, J.J., in 2011 in a paper entitled "Molecular Mechanism of Selectivity among G Protein-Coupled Receptor Kinase 2 Inhibitors." (abstract).
This crystal structure was determined using X-ray diffraction at a resolution of 2.48 Å and deposited in 2010.
The experimental data on which the structure is based was also deposited.
This PDB entry contains a complex of 3 biomacromolecules, namely Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, and Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2.
It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.
The molecule most likely forms heterotrimers.
The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):
This entry contains 3 unique UniProt proteins: