3pup Summary

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Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)

The structure was published by Feng, L., Geisselbrecht, Y., Blanck, S., et al., Knapp, S., Essen, L.O., and Meggers, E., in 2011 in a paper entitled "Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.99 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Molecular function (GO) Biological process (GO) Cellular component (GO)
A, B (P49841) ATP bindingsearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein serine/threonine kinase activitysearch protein bindingsearch kinase activitysearch ubiquitin protein ligase bindingsearch tau-protein kinase activitysearch NF-kappaB bindingsearch tau protein bindingsearch beta-catenin bindingsearch protein kinase bindingsearch p53 bindingsearch integrin bindingsearch ionotropic glutamate receptor bindingsearch nucleotide bindingsearch RNA polymerase II transcription factor bindingsearch transferase activitysearch protein kinase A catalytic subunit bindingsearch protein phosphorylationsearch negative regulation of canonical Wnt signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch negative regulation of NFAT protein import into nucleussearch canonical Wnt signaling pathwaysearch positive regulation of protein bindingsearch axon guidancesearch innate immune responsesearch glycogen metabolic processsearch negative regulation of MAP kinase activitysearch phosphorylationsearch positive regulation of protein complex assemblysearch positive regulation of Rac GTPase activitysearch negative regulation of dendrite morphogenesissearch cellular response to interleukin-3search positive regulation of protein catabolic processsearch Wnt signaling pathwaysearch Fc-epsilon receptor signaling pathwaysearch hypermethylation of CpG islandsearch positive regulation of protein export from nucleussearch protein localization to microtubulesearch circadian rhythmsearch negative regulation of protein bindingsearch regulation of gene expression by genetic imprintingsearch negative regulation of glycogen biosynthetic processsearch intracellular signal transductionsearch ER overload responsesearch regulation of microtubule-based processsearch nervous system developmentsearch multicellular organismal developmentsearch myoblast fusionsearch negative regulation of glycogen (starch) synthase activitysearch re-entry into mitotic cell cyclesearch fat cell differentiationsearch establishment of cell polaritysearch response to lithium ionsearch axonogenesissearch negative regulation of signal transductionsearch peptidyl-serine phosphorylationsearch positive regulation of cell-matrix adhesionsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch positive regulation of peptidyl-threonine phosphorylationsearch carbohydrate metabolic processsearch rhythmic processsearch phosphatidylinositol-mediated signalingsearch cell migrationsearch establishment or maintenance of cell polaritysearch protein export from nucleussearch superior temporal gyrus developmentsearch cell differentiationsearch negative regulation of protein complex assemblysearch positive regulation of apoptotic processsearch cellular response to mechanical stimulussearch fibroblast growth factor receptor signaling pathwaysearch positive regulation of peptidyl-serine phosphorylationsearch positive regulation of transcription from RNA polymerase II promotersearch negative regulation of apoptotic processsearch negative regulation of cardiac muscle hypertrophysearch hippocampus developmentsearch epithelial to mesenchymal transitionsearch negative regulation of type B pancreatic cell developmentsearch organ morphogenesissearch extrinsic apoptotic signaling pathway in absence of ligandsearch myotube differentiationsearch epidermal growth factor receptor signaling pathwaysearch regulation of neuronal synaptic plasticitysearch positive regulation of stem cell differentiationsearch response to drugsearch beta-catenin destruction complexsearch perinuclear region of cytoplasmsearch cytosolsearch nucleussearch membranesearch ribonucleoprotein complexsearch centrosomesearch neuronal cell bodysearch plasma membranesearch cytoplasmsearch dendritic spinesearch protein complexsearch membrane-bounded organellesearch dendritic shaftsearch growth conesearch membrane raftsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch