3pup Summary

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Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)

The structure was published by Feng, L., Geisselbrecht, Y., Blanck, S., et al., Knapp, S., Essen, L.O., and Meggers, E., in 2011 in a paper entitled "Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.99 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch establishment or maintenance of cell polaritysearch axonogenesissearch intracellular signal transductionsearch cellular response to interleukin-3search ER overload responsesearch negative regulation of neuron projection developmentsearch negative regulation of neuron maturationsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch negative regulation of cardiac muscle hypertrophysearch multicellular organismal developmentsearch positive regulation of protein bindingsearch negative regulation of canonical Wnt signaling pathwaysearch positive regulation of Rac GTPase activitysearch axon guidancesearch positive regulation of protein complex assemblysearch extrinsic apoptotic signaling pathway in absence of ligandsearch hypermethylation of CpG islandsearch superior temporal gyrus developmentsearch regulation of microtubule-based processsearch protein localization to microtubulesearch peptidyl-serine phosphorylationsearch regulation of gene expression by genetic imprintingsearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch carbohydrate metabolic processsearch positive regulation of apoptotic processsearch phosphorylationsearch canonical Wnt signaling pathwaysearch negative regulation of glycogen biosynthetic processsearch negative regulation of MAP kinase activitysearch circadian rhythmsearch Wnt signaling pathwaysearch establishment of cell polaritysearch cellular response to mechanical stimulussearch positive regulation of protein catabolic processsearch negative regulation of protein bindingsearch Fc-epsilon receptor signaling pathwaysearch positive regulation of protein export from nucleussearch cell migrationsearch fat cell differentiationsearch negative regulation of apoptotic processsearch re-entry into mitotic cell cyclesearch response to lithium ionsearch negative regulation of glycogen (starch) synthase activitysearch phosphatidylinositol-mediated signalingsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch cell differentiationsearch neurotrophin TRK receptor signaling pathwaysearch positive regulation of transcription from RNA polymerase II promotersearch nervous system developmentsearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of signal transductionsearch positive regulation of cell-matrix adhesionsearch rhythmic processsearch negative regulation of protein complex assemblysearch negative regulation of dendrite morphogenesissearch epidermal growth factor receptor signaling pathwaysearch positive regulation of stem cell differentiationsearch organ morphogenesissearch regulation of neuronal synaptic plasticitysearch glycogen metabolic processsearch hippocampus developmentsearch fibroblast growth factor receptor signaling pathwaysearch epithelial to mesenchymal transitionsearch myotube differentiationsearch negative regulation of type B pancreatic cell developmentsearch positive regulation of peptidyl-serine phosphorylationsearch negative regulation of NFAT protein import into nucleussearch innate immune responsesearch myoblast fusionsearch response to drugsearch protein export from nucleussearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch ATP bindingsearch protein bindingsearch protein serine/threonine kinase activitysearch ubiquitin protein ligase bindingsearch ionotropic glutamate receptor bindingsearch nucleotide bindingsearch kinase activitysearch NF-kappaB bindingsearch beta-catenin bindingsearch tau-protein kinase activitysearch protein kinase bindingsearch p53 bindingsearch integrin bindingsearch tau protein bindingsearch protein kinase A catalytic subunit bindingsearch transferase activitysearch RNA polymerase II transcription factor bindingsearch cytoplasmsearch nucleussearch dendritic spinesearch perinuclear region of cytoplasmsearch beta-catenin destruction complexsearch cytosolsearch membrane-bounded organellesearch dendritic shaftsearch protein complexsearch nucleoplasmsearch membranesearch plasma membranesearch centrosomesearch cell bodysearch membrane raftsearch neuronal cell bodysearch ribonucleoprotein complexsearch growth conesearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch