3pup Summary

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Structure of Glycogen Synthase Kinase 3 beta (GSK3B) in complex with a ruthenium octasporine ligand (OS1)

The structure was published by Feng, L., Geisselbrecht, Y., Blanck, S., et al., Knapp, S., Essen, L.O., and Meggers, E., in 2011 in a paper entitled "Structurally sophisticated octahedral metal complexes as highly selective protein kinase inhibitors." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.99 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of Glycogen synthase kinase-3 beta.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%
B Glycogen synthase kinase-3 beta P49841 (1-420) (GSK3B_HUMAN)search Homo sapienssearch 91% 420 82%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P49841 (1 - 420) Glycogen synthase kinase-3 beta Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A, B (P49841) Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search PF00069: Protein kinase domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P49841) protein phosphorylationsearch glycogen metabolic processsearch organ morphogenesissearch innate immune responsesearch fat cell differentiationsearch protein export from nucleussearch negative regulation of signal transductionsearch negative regulation of NFAT protein import into nucleussearch canonical Wnt signaling pathwaysearch protein localization to microtubulesearch cell differentiationsearch positive regulation of Rac GTPase activitysearch positive regulation of protein complex assemblysearch negative regulation of apoptotic processsearch negative regulation of MAP kinase activitysearch positive regulation of peptidyl-serine phosphorylationsearch axon guidancesearch regulation of neuronal synaptic plasticitysearch axonogenesissearch Wnt signaling pathwaysearch positive regulation of protein bindingsearch negative regulation of canonical Wnt signaling pathwaysearch ER overload responsesearch myotube differentiationsearch myoblast fusionsearch intracellular signal transductionsearch positive regulation of apoptotic processsearch Fc-epsilon receptor signaling pathwaysearch negative regulation of protein bindingsearch positive regulation of protein export from nucleussearch cellular response to interleukin-3search regulation of microtubule-based processsearch negative regulation of dendrite morphogenesissearch negative regulation of glycogen biosynthetic processsearch circadian rhythmsearch response to drugsearch establishment or maintenance of cell polaritysearch positive regulation of protein catabolic processsearch positive regulation of transcription from RNA polymerase II promotersearch peptidyl-serine phosphorylationsearch superior temporal gyrus developmentsearch nervous system developmentsearch positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwaysearch phosphatidylinositol-mediated signalingsearch positive regulation of cell-matrix adhesionsearch neurotrophin TRK receptor signaling pathwaysearch canonical Wnt signaling pathway involved in positive regulation of apoptotic processsearch positive regulation of peptidyl-threonine phosphorylationsearch negative regulation of cardiac muscle hypertrophysearch hypermethylation of CpG islandsearch positive regulation of proteasomal ubiquitin-dependent protein catabolic processsearch regulation of gene expression by genetic imprintingsearch carbohydrate metabolic processsearch negative regulation of glycogen (starch) synthase activitysearch epidermal growth factor receptor signaling pathwaysearch phosphorylationsearch extrinsic apoptotic signaling pathway in absence of ligandsearch establishment of cell polaritysearch multicellular organismal developmentsearch hippocampus developmentsearch positive regulation of stem cell differentiationsearch cell migrationsearch cellular response to mechanical stimulussearch negative regulation of neuron maturationsearch epithelial to mesenchymal transitionsearch rhythmic processsearch negative regulation of type B pancreatic cell developmentsearch fibroblast growth factor receptor signaling pathwaysearch response to lithium ionsearch re-entry into mitotic cell cyclesearch negative regulation of neuron projection developmentsearch negative regulation of protein complex assemblysearch ATP bindingsearch protein serine/threonine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein kinase activitysearch protein bindingsearch NF-kappaB bindingsearch tau-protein kinase activitysearch kinase activitysearch transferase activitysearch ubiquitin protein ligase bindingsearch nucleotide bindingsearch tau protein bindingsearch beta-catenin bindingsearch protein kinase bindingsearch ionotropic glutamate receptor bindingsearch p53 bindingsearch protein kinase A catalytic subunit bindingsearch RNA polymerase II transcription factor bindingsearch integrin bindingsearch membrane raftsearch cytosolsearch cytoplasmsearch membrane-bounded organellesearch nucleussearch beta-catenin destruction complexsearch plasma membranesearch centrosomesearch membranesearch dendritic spinesearch neuronal cell bodysearch growth conesearch perinuclear region of cytoplasmsearch cell bodysearch protein complexsearch dendritic shaftsearch ribonucleoprotein complexsearch

Chain InterPro annotation
A, B Protein kinase domainsearch Serine/threonine/dual specificity protein kinase, catalytic domainsearch Serine/threonine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch