3psr Summary



The structure was published by Brodersen, D.E., Nyborg, J., and Kjeldgaard, M., in 1999 in a paper entitled "Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PSORIASIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PSORIASIN P31151 (2-101) (S10A7_HUMAN)search Homo sapienssearch 95% 100 96%
B PSORIASIN P31151 (2-101) (S10A7_HUMAN)search Homo sapienssearch 95% 100 96%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31151 (2 - 101) PSORIASIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P31151) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Biological process (GO) Molecular function (GO) Cellular component (GO)
A, B (P31151) response to reactive oxygen speciessearch angiogenesissearch epidermis developmentsearch positive regulation of T cell chemotaxissearch keratinocyte differentiationsearch response to lipopolysaccharidesearch innate immune responsesearch defense response to Gram-negative bacteriumsearch sequestering of metal ionsearch positive regulation of ERK1 and ERK2 cascadesearch positive regulation of granulocyte chemotaxissearch positive regulation of monocyte chemotaxissearch calcium ion bindingsearch protein bindingsearch zinc ion bindingsearch metal ion bindingsearch RAGE receptor bindingsearch extracellular regionsearch nucleussearch cytoplasmsearch endoplasmic reticulumsearch cytosolsearch focal adhesionsearch extracellular vesicular exosomesearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch