3psr Summary

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HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)

The structure was published by Brodersen, D.E., Nyborg, J., and Kjeldgaard, M., in 1999 in a paper entitled "Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1998.

The experimental data on which the structure is based was also deposited.

This PDB entry contains multiple copies of the structure of PSORIASIN.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule most likely forms homodimers.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A PSORIASIN P31151 (2-101) (S10A7_HUMAN)search Homo sapienssearch 95% 100 96%
B PSORIASIN P31151 (2-101) (S10A7_HUMAN)search Homo sapienssearch 95% 100 96%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
P31151 (2 - 101) PSORIASIN Homo sapiens

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B (P31151) S100 proteinssearch EF-handsearch PF01023: S-100/ICaBP type calcium binding domainsearch

Chain ID Cellular component (GO) Biological process (GO) Molecular function (GO)
A, B (P31151) extracellular regionsearch endoplasmic reticulumsearch cytoplasmsearch nucleussearch cytosolsearch extracellular vesicular exosomesearch focal adhesionsearch epidermis developmentsearch response to lipopolysaccharidesearch positive regulation of T cell chemotaxissearch positive regulation of ERK1 and ERK2 cascadesearch innate immune responsesearch angiogenesissearch defense response to Gram-negative bacteriumsearch positive regulation of monocyte chemotaxissearch sequestering of metal ionsearch response to reactive oxygen speciessearch positive regulation of granulocyte chemotaxissearch keratinocyte differentiationsearch zinc ion bindingsearch protein bindingsearch RAGE receptor bindingsearch metal ion bindingsearch calcium ion bindingsearch

Chain InterPro annotation
A, B S100/Calbindin-D9k, conserved sitesearch EF-hand domainsearch EF-hand domain pairsearch S100/CaBP-9k-type, calcium binding, subdomainsearch EF-Hand 1, calcium-binding sitesearch