3pn7 Summary

pdbe.org/3pn7
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Visualizing new hinges and a potential major source of compliance in the lever arm of myosin

The structure was published by Brown, J.H., Senthil Kumar, V.S., O'Neall-Hennessey, E., et al., Nguyen-McCarty, M., Szent-Gyorgyi, A.G., and Cohen, C., in 2011 in a paper entitled "Visualizing key hinges and a potential major source of compliance in the lever arm of myosin." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.25 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

This PDB entry contains a complex of 3 biomacromolecules, namely Myosin heavy chain, Myosin regulatory light chain, and Myosin essential light chain.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Myosin heavy chain Q26080 (771-839) (Q26080_PLAMG)search Placopecten magellanicussearch < 90% 69 100%
D Myosin heavy chain Q26080 (771-839) (Q26080_PLAMG)search Placopecten magellanicussearch < 90% 69 100%
B Myosin regulatory light chain Q26069 (2-162) (Q26069_PLAMG)search Placopecten magellanicussearch 99% 161 90%
E Myosin regulatory light chain Q26069 (2-162) (Q26069_PLAMG)search Placopecten magellanicussearch 99% 161 90%
C Myosin essential light chain Q26066 (2-157) (Q26066_PLAMG)search Placopecten magellanicussearch 99% 156 97%
F Myosin essential light chain Q26066 (2-157) (Q26066_PLAMG)search Placopecten magellanicussearch 99% 156 97%


This entry contains 3 unique UniProt proteins:

UniProt accession Name Organism PDB
Q26080 (771 - 839) Myosin heavy chain Placopecten magellanicus
Q26069 (2 - 162) Myosin regulatory light chain Placopecten magellanicus
Q26066 (2 - 157) Myosin essential light chain Placopecten magellanicus

Chain Structural classification (CATH) Sequence family (Pfam)
A, D
B, E (Q26069) EF-handsearch PF13499: EF-hand domain pairsearch
C, F (Q26066) EF-handsearch PF13499: EF-hand domain pairsearch

Chain ID Molecular function (GO)
B, E (Q26069) calcium ion bindingsearch metal ion bindingsearch
C, F (Q26066) calcium ion bindingsearch metal ion bindingsearch

Chain InterPro annotation
A, D IQ motif, EF-hand binding sitesearch Myosin-like IQ motif-containing domainsearch P-loop containing nucleoside triphosphate hydrolasesearch
B, E EF-hand domainsearch EF-hand domain pairsearch EF-Hand 1, calcium-binding sitesearch
C, F EF-hand domainsearch EF-hand domain pairsearch