3pls Summary


RON in complex with ligand AMP-PNP

The structure was published by Wang, J., Steinbacher, S., Augustin, M., et al., Epstein, D., Mulvihill, M.J., and Crew, A.P., in 2010 in a paper entitled "The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis" (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.24 Å and deposited in 2010.

The experimental data on which the structure is based was also deposited.

The PDB entry contains the structure of Macrophage-stimulating protein receptor. This molecule has the UniProt identifier Q04912 (RON_HUMAN)search. The sample contained 298 residues which is < 90% of the natural sequence. Out of 298 residues 297 were observed and are deposited in the PDB.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule is most likely monomeric.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):

Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A Macrophage-stimulating protein receptor Q04912 (1060-1357) (RON_HUMAN)search Homo sapienssearch < 90% 298 100%

This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q04912 (1060 - 1357) Macrophage-stimulating protein receptor Homo sapiens

Chain Structural classification (CATH) Sequence family (Pfam)
A Phosphorylase Kinase; domain 1search, Transferase(Phosphotransferase) domain 1search Protein tyrosine kinasesearch

Chain ID Molecular function (GO) Biological process (GO)
A (Q04912) protein kinase activitysearch ATP bindingsearch protein tyrosine kinase activitysearch transferase activity, transferring phosphorus-containing groupssearch protein phosphorylationsearch

Chain InterPro annotation
A Protein kinase domainsearch Serine-threonine/tyrosine-protein kinase catalytic domainsearch Tyrosine-protein kinase, active sitesearch Protein kinase-like domainsearch Protein kinase, ATP binding sitesearch Tyrosine-protein kinase, catalytic domainsearch