3pgh Summary

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CYCLOOXYGENASE-2 (PROSTAGLANDIN SYNTHASE-2) COMPLEXED WITH A NON-SELECTIVE INHIBITOR, FLURBIPROFEN

The structure was published by Kurumbail, R.G., Stevens, A.M., Gierse, J.K., et al., Seibert, K., Isakson, P.C., and Stallings, W.C., in 1996 in a paper entitled "Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents." (abstract).

This crystal structure was determined using X-ray diffraction at a resolution of 2.5 Å and deposited in 1996.

The experimental data on which the structure is based was not deposited.

This PDB entry contains multiple copies of the structure of CYCLOOXYGENASE-2.

It also contains one or more heterogenic compounds (e.g., ligands, co-factors, ions, modified amino acids, etc.); see here for a complete list.

The molecule has more than one probable quaternary state observed. For more details see the quaternary structure page.

The following tables show cross-reference information to other databases (to obtain a list of all PDB entries sharing the same property or classification, click on the magnifying glass icon):


Chain Name UniProt Name of source organism % of UniProt sequence present in the sample Residues in the sample molecules % of residues observed
A CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
B CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
C CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%
D CYCLOOXYGENASE-2 Q05769 (18-604) (PGH2_MOUSE)search Mus musculussearch 94% 587 94%


This entry contains 1 unique UniProt protein:

UniProt accession Name Organism PDB
Q05769 (18 - 604) CYCLOOXYGENASE-2 Mus musculus

Chain Structural classification (SCOP) Structural classification (CATH) Sequence family (Pfam)
A, B, C, D (Q05769) Myeloperoxidase-likesearch, EGF-type modulesearch Lamininsearch, Myeloperoxidase, subunit Csearch PF03098: Animal haem peroxidasesearch

Chain ID Biological process (GO) Cellular component (GO) Molecular function (GO)
A, B, C, D (Q05769) prostaglandin biosynthetic processsearch oxidation-reduction processsearch inflammatory responsesearch cyclooxygenase pathwaysearch lipid metabolic processsearch response to lipopolysaccharidesearch positive regulation of synaptic transmission, glutamatergicsearch positive regulation of cell deathsearch regulation of cell proliferationsearch positive regulation of smooth muscle contractionsearch positive regulation of nitric oxide biosynthetic processsearch response to radiationsearch positive regulation vascular endothelial growth factor productionsearch memorysearch positive regulation of transforming growth factor beta productionsearch maintenance of blood-brain barriersearch embryo implantationsearch positive regulation of vasoconstrictionsearch response to drugsearch response to fructosesearch cellular response to UVsearch ovulationsearch regulation of blood pressuresearch response to manganese ionsearch response to tumor necrosis factorsearch learningsearch response to glucocorticoidsearch positive regulation of fibroblast growth factor productionsearch angiogenesissearch response to organic cyclic compoundsearch decidualizationsearch response to estradiolsearch response to fatty acidsearch cellular response to fluid shear stresssearch bone mineralizationsearch response to cytokinesearch positive regulation of cell proliferationsearch positive regulation of fever generationsearch brown fat cell differentiationsearch cellular response to hypoxiasearch response to organonitrogen compoundsearch positive regulation of brown fat cell differentiationsearch positive regulation of platelet-derived growth factor productionsearch positive regulation of cell migration involved in sprouting angiogenesissearch negative regulation of smooth muscle contractionsearch negative regulation of cell cyclesearch negative regulation of cell proliferationsearch hair cyclesearch cellular response to mechanical stimulussearch positive regulation of smooth muscle cell proliferationsearch fatty acid metabolic processsearch cellular response to ATPsearch positive regulation of apoptotic processsearch sensory perception of painsearch negative regulation of calcium ion transportsearch response to organic substancesearch negative regulation of synaptic transmission, dopaminergicsearch positive regulation of NF-kappaB import into nucleussearch response to vitamin Dsearch response to lithium ionsearch keratinocyte differentiationsearch prostaglandin metabolic processsearch fatty acid biosynthetic processsearch positive regulation of synaptic plasticitysearch response to oxidative stresssearch cytoplasmsearch membranesearch endoplasmic reticulum membranesearch intracellular membrane-bounded organellesearch neuron projectionsearch organelle membranesearch caveolasearch endoplasmic reticulumsearch protein complexsearch prostaglandin-endoperoxide synthase activitysearch protein homodimerization activitysearch oxidoreductase activitysearch lipid bindingsearch dioxygenase activitysearch enzyme bindingsearch peroxidase activitysearch oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygensearch metal ion bindingsearch heme bindingsearch

Chain InterPro annotation
A, B, C, D Epidermal growth factor-like domainsearch Haem peroxidasesearch Haem peroxidase, animalsearch Prostaglandin G/H synthase 2search